The OzFoodNet Working Group is (in alphabetical order): Kylie Begg (ACT), Robert Bell (Qld), Philippa Binns (NT), Andrew Black (ACT), M Bookallil (NT), Barry Combs (SA), Craig Dalton (Hunter New England), Gerard Fitzsimmons (DoHA), Robyn Gibbs (WA), Joy Gregory (Vic), Gillian Hall (NCEPH), Geoff Hogg (MDU), Martyn Kirk (DoHA), Karin Lalor (Vic), Tony Merritt (Hunter New England), Sally Munnoch ...

Targeting the DNA damage response (DDR) is a new therapeutic approach in cancer that shows great promise for tumour selectivity. Key components of the DDR are the ataxia telangiectasia mutated and Rad3 related (ATR) and checkpoint kinase 1 (CHK1) kinases. This review article describes the role of ATR and its major downstream target, CHK1, in the DDR and why cancer cells are particularly reliant...

This paper uses the GTAP computable general equilibrium model to assess the impact of a Doha Development Agenda agreement on agricultural trade liberalisation. In particular, we examine the consequences for developing countries. The simulation incorporates further liberalisation in the areas of market access, export competition and domestic support. Most developing regions can expect strong pos...

Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the genomic sequence in organisms is key for the perpetuation of life. The machinery...

The paper looks at the OECD domestic political economy associated to ongoing WTO farm negotiations, focusing on the OECD-based coalitions which could be helpful for WTO negotiators. Support from individual final consumers and taxpayers is far from being guaranteed–because consumers are spending less and less on food, and because taxpayers support, more or less willingly, non-trade concerns, suc...

The inherent tension between trade preferences and the Most-Favoured Nation (MFN) principle has been mainly examined in the context of regional free trade agreements and customs unions. Much less attention has been given to non-reciprocal special trade preferences given by developed countries to developing countries. WTO rules on these special preferences are less explicit than WTO rules govern...

This paper presents a conceptual framework for design and develop Creativity Clay Module to teach Special Educational Needs (SENs) students with learning disabilities in Education Integration Program (SEIP) Malaysia primary schools. The will be designed especially based on Torrance Theory, Constructivism Sidek’s Development Model. Thus, this presenting literature review Creativity, Clay, Model,...

Mec1ATR mediates the DNA damage response (DDR), integrating chromosomal signals and mechanical stimuli. We show that the PP2A phosphatases, ceramide-activated enzymes, couple cell metabolism with the DDR. Using genomic screens, metabolic analysis, and genetic and pharmacological studies, we found that PP2A attenuates the DDR and that three metabolic circuits influence the DDR by modulating PP2A...

The DNA damage response (DDR) is a conglomerate of pathways designed to detect DNA damage and signal its presence to cell cycle checkpoints and to the repair machinery, allowing the cell to pause and mend the damage, or if the damage is too severe, to trigger apoptosis or senescence. Various DDR branches are regulated by kinases of the phosphatidylinositol 3-kinase-like protein kinase family, i...

The study investigates India’s trade prospect with ASEAN countries by analyzing the pattern and trends in India’s bilateral merchandise trade with ASEAN countries and their revealed comp that during last three decades India’s share in ASEAN has increased, but it has been less than that of Japan and China. T more marked in the case of im vis-à-vis ASEAN countries. had been worst in case of its t...