Deoxynivalenol (DON) and other ribotoxic trichothecenes cause immune stimulation and suppression in leukocytes by upregulating gene expression and apoptosis, respectively. The purpose of this study was to test the hypothesis that MAPKs mediate both apoptosis and survival in DON-exposed macrophages. At concentrations which partially inhibit translation, DON induced phosphorylation of p38 and ERK...

Samples of wheat naturally infected by Fusarium graminearum Schwabe were obtained from mills in Oklahoma, Missouri, Kansas, and Minnesota and fields in Nebraska and Kansas in 1982; they were analyzed for deoxynivalenol (DON). The wheat was milled, and DON was found throughout all the milling fractions (bran, shorts, reduction flour, and break flour). The DON recoveries for each mill run ranged ...

abstractthe occurrence of deoxynivalenol (don) in retail foods in tehran (iran) was determined using high-performance liquid chromatography technique and immunoaffinity column as the clean-up step. a method was validated for analysis of don in rice, bread, puffed corn snack and wheat flour. the average recoveries and precision (rsd) for don in different foods ranged 84.2-93.1% and 2.9-12.0%, re...

The mould Fusarium graminearum is found worldwide as a pathogen of cereal grains, in particular of wheat and maize, and it produces a mycotoxin known as deoxynivalenol (DON or vomitoxin). Each year, the presence of this compound and related trichothecenes causes substantial losses to agricultural productivity. Rapid methods for the measurement of the toxin in grains are required to monitor and ...

[1] Here we describe, test, and apply a system of spatially explicit, global models for predicting river export of three dissolved organic matter (DOM) components: dissolved organic carbon (DOC), dissolved organic nitrogen (DON), and dissolved organic phosphorus (DOP). The DON and DOP models represent the first attempt to model DON and DOP export in a spatially explicit, global manner. DOC, DON...

Dissolved organic nitrogen (DON) is present in soils and streams around the world. We are only now beginning to explore the important roles this chemically heterogeneous mixture of compounds plays in terrestrial nitrogen (N) cycling. Over centuries, DON leaching may represent a significant "leak" of N, which occurs because plants and microbes cannot prevent DON losses, even in times of high N d...

Dissolved organic nitrogen (DON) is an abundant but poorly understood pool of N in many ecosystems. We assessed DON cycling in a N-limited headwater forest stream via whole-ecosystem additions of dissolved inorganic nitrogen (DIN) and labile dissolved organic matter (DOM), hydrologic transport and biogeochemical modeling, and laboratory experiments with native sediments. We sampled surface and ...

BACKGROUND The trichothecene mycotoxin deoxynivalenol (DON) may be concentrated in distillers dried grains with solubles (DDGS; a co-product of fuel ethanol fermentation) when grain containing DON is used to produce fuel ethanol. Even low levels of DON (≤ 5 ppm) in DDGS sold as feed pose a significant threat to the health of monogastric animals. New and improved strategies to reduce DON in DDGS...

Dissolved organic nitrogen (DON) is an abundant but poorly understood pool of N in many ecosystems. We assessed DON cycling in a N-limited headwater forest stream via whole-ecosystem additions of dissolved inorganic nitrogen (DIN) and labile dissolved organic matter (DOM), hydrologic transport and biogeochemical modeling, and laboratory experiments with native sediments. We sampled surface and ...

Mycotoxins pose an important danger to human and animal health. Poultry feeds are frequently contaminated with deoxynivalenol (DON) mycotoxin. It is thus of great importance to evaluate the effects of DON on the welfare related parameters in poultry industry. In the present study, the effects of contamination of broiler diet with 10 mg DON/kg feed on plasma corticosterone and heterophil to lymp...