Deoxynivalenol (DON), a trichothecene mycotoxin that commonly contaminates cereal grains, is a public health concern because of its adverse effects on the gastrointestinal and immune systems. The objective of this study was to compare effects of DON on anorectic responses in aged (22 mos) and adult (3 mos) mice. Aged mice showed increased feed refusal with both acute i.p. (1 mg/kg and 5 mg/kg) ...

We intended to assess how exposure of piglets to deoxynivalenol (DON)-contaminated feed impacted their growth, immune response and gut development. Piglets were fed traditional Phase I, Phase II and Phase III diets with the control group receiving 0.20-0.40 ppm DON (referred to as the Control group) and treatment group receiving much higher level of DON-contaminated wheat (3.30-3.80 ppm; referr...

Globally, the trichothecene mycotoxins deoxynivalenol (DON) and nivalenol (NIV) are among the most widely distributed mycotoxins that contaminate small grain cereals. In this study, a bacterial consortium, PGC-3, with de-epoxydation activity was isolated from soil by an in situ soil enrichment method. Screening of 14 soil samples that were sprayed with DON revealed that 4 samples were able to b...

The aim of this study was to investigate the efficacy of selenium nanoparticles (SeNPs) that had been biologically synthesized by Bacillus licheniformis to counteract deoxynivalenol (DON) toxicity in laying hens. Ninety-six healthy, 20-week-old laying hens were randomly assigned to four treatment groups, each of which included 3 replicates of 8 layers, and fed four different diets: an uncontami...

Fusarium head blight (FHB), caused primarily by Fusarium graminearum, has been the most destructive disease of barley (Hordeum vulgare L.) in the USA since the early 1990s, resulting in large economic losses for growers. The fungus produces the mycotoxin deoxynivalenol (DON), a protein synthesis inhibitor, which is harmful to humans and livestock. Chemically modifying DON could reduce DON accum...

In aquatic ecosystems, carbon (C) availability strongly influences nitrogen (N) dynamics. One manifestation of this linkage is the importance in the dissolved organic matter (DOM) pool of dissolved organic nitrogen (DON), which can serve as both a C and an N source, yet our knowledge of how specific properties of DOM influence N dynamics are limited. To empirically examine the impact of labile ...

The mycotoxin deoxynivalenol (DON), one of the most common food contaminants, primarily targets the gastrointestinal tract to affect animal and human health. This study was conducted to examine the protective function of glutamic acid on intestinal injury and oxidative stress caused by DON in piglets. Twenty-eight piglets were assigned randomly into 4 dietary treatments (7 pigs/treatment): 1) u...

Fusarium head blight (FHB) is an important disease of wheat worldwide caused mainly by Fusarium graminearum (syn. Gibberella zeae). This fungus can be highly aggressive and can produce several mycotoxins such as deoxynivalenol (DON), a well known harmful metabolite for humans, animals, and plants. The fungus can survive overwinter on wheat residues and on the soil, and can usually attack the wh...

Like the movements of the MinD protein, rapid move-1965 to 1996, the period covered by the book, Don Metcalf was Head of the Cancer Research Unit and ments are occurring in the intellectual landscape of cell Assistant Director of the Institute, which was headed biology, and cell polarity is no exception. This volume during this period by Gus Nossal. The focus of Metcalf's is a snapshot of the f...

Universidad Autónoma de Aguascalientes, Centro de Ciencias Básicas, Dpto. Sistemas de Información Av. Universidad #940, Cd. Universitaria, CP. 20131, Aguascalientes, México. Universidad Politécnica de Aguascalientes, Dirección de Posgrado e Investigación, Calle Paseo San Gerardo No. 207. Fracc. San Gerardo. C.P. 20342. Aguascalientes, México Instituto Tecnológico de Aguascalientes, Departamento...