نتایج جستجو برای: doxorubicin
تعداد نتایج: 29822 فیلتر نتایج به سال:
Introduction: Taxanes have emerged as one of the most active agents in the treatment of patients with breast cancer. Nevertheless, questions remain with regard to their toxicity profiles. This study aimed to compare prevalence and severity of adverse effects of two chemotherapy regimens including taxanes (docetaxel or paclitaxel) in breast cancer patients. Materials and Methods: Fifty patients ...
Doxorubicin, used in pediatric chemotherapy regimens, has cardiotoxic effects. Dexrazoxane is co-administrated with doxorubicin to prevent its cardiotoxicity. Here we have explored some alternative food or drugs to be used in absence of dexrazoxane since it’s not readily available in Iran at this time. Keywords: Pediatric, chemotherapy, doxorubicin, cardiotoxicity, dexrazoxane, Iran.
Introduction: It has been reported that doxorubicin can cause liver damage; however, exercise and crocin consumption can improve antioxidant defense.The aim of the present study was to investigate the antioxidant effect of continuous training with crocin consumption on the liver tissue of doxorubicin-poisoned rats. Methods: In this experimental...
Introduction: Cancer is one of the most harmful disease throughout the world. Doxorubicin is an anti-cancer agent, used in the treatment of various types of the cancer such as bone cancer. There are several adverse effects related to clinical usage of Doxorubicin for long time. The present study aimed to investigate the reducing side effects and enhancing the therapeutic effect by liposomal car...
doxorubicin, used in pediatric chemotherapy regimens, has cardiotoxic effects. dexrazoxane is co-administrated with doxorubicin to prevent its cardiotoxicity. here we have explored some alternative food or drugs to be used in absence of dexrazoxane since it’s not readily available in iran at this time. keywords: pediatric, chemotherapy, doxorubicin, cardiotoxicity, dexrazoxane, iran.
objective(s):the use of doxorubicin (dox) is limited by its dose-dependent cardio toxicity in which reactive oxygen species (ros) play an important role in the pathological process. the aim of this study was to evaluate the protective effect of three medicinal plants, nigella sativa (n), glycyrrhiza glabra (g) and zingiber officinale (z), and their combination (ngz), against dox-induced apoptos...
objective: doxorubicin (dox) is an effective anticancer drug but its clinical application is limited because it induces apoptosis in cardiomyocytes and leads to permanent degenerative cardiomyopathy and heart failure possibly due to oxidative stress. recent studies showed that capparis spinosa (c. spinose)exhibits potent antioxidant activity. so, in this study, we explored the protective effect...
a validated hplc method was developed to determine doxorubicin concentration in a small volume of rat plasma (60 µl) with convenient fluorescence detection. sample preparation includes a simple one-step liquid-liquid extraction using minimum amount of organic solvent, with extraction recoveries more than 95%. the analysis was accomplished using perfectsil c18 column maintained at 35 °c and a mo...
Objective(s):Berberine, a naturally occurring isoquinoline alkaloid, has shown antitumor properties in some in vitro systems. But the effect of berberine on breast cancer has not yet been completely studied. In this study, we evaluated anticancer properties of berberine in comparison to doxorubicin. Materials and Methods: The antiproliferative effects of berberine and doxorubicin alone and in ...
Doxorubicin (DOX) is one of the drugs necessary for treatment 10 most common types cancer. The leading adverse effect limiting clinical use DOX cardiotoxicity. Given that literature data indicate a protective role carotenoids in doxorubicin-induced toxicity, our study we compared cardioprotective mixture pumpkin and commercially available antioxidant preparation. Animals were distributed 8 grou...
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