BACKGROUND Ivermectin (IVM) has been the drug of choice for the treatment of onchocerciasis. However, there have been reports of persistent microfilaridermia in individuals from an endemic area in Ghana after many rounds of IVM, raising concerns of suboptimal response or even the emergence of drug resistance. Because it is considered risky to continue relying only on IVM to combat this phenomen...

During a period of 4 years (1983-1986), we have seen 18 patients with esophageal ulcer following the intake of doxycycline capsules at the University Hospitals of Shiraz Medical School. During the same period only one other patient with a drug-induced esophageal ulcer was seen and this was found to be due to a mefenemic acid capsule. Diagnosis was made by esophagoscopy and after two weeks,...

Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective...

The effect of doxycycline on immune response has been studied in mice, cell-mediated immunity being evaluated with the split heart allograft technique. Survival duration of heart transplants in animals treated with 2.5 mg of doxycycline per kg per day from the day of transplantation until rejection was slightly but significantly longer than in untreated animals, 18.8 days (P less than 0.05) as ...

The present paper describes a comparative characterization of cytotoxic effects of doxycycline and cisplatin on osteosarcoma cells by using impedance sensing techniques. The impedance sensing device was obtained from Applied Physics and the osteosarcoma cells were cultured on the electrodes of the purchased devices. The impedimetric cytotoxic natures of both the drugs on cells are investigated ...

DNA-PK is an enzyme that is required for proper DNA-repair and is thought to confer radio-resistance in cancer cells. As a consequence, it is a high-profile validated target for new pharmaceutical development. However, no FDA-approved DNA-PK inhibitors have emerged, despite many years of drug discovery and lead optimization. This is largely because existing DNA-PK inhibitors suffer from poor ph...

Background The liver is target following exposure to pentavalent vanadium (V5+). Doxycycline an antioxidant that prevents the progression of disease through inhibition lipid peroxidation. Aim present study was designed evaluate protective effects doxycycline against vanadium-induced hepatoxicity. Methods Sixty two male Sprague-Dawley rats (250–300 g) were equally divided into four groups: contr...

BACKGROUND An association between ocular adnexal MALT lymphoma (OAL) and Chlamydia psittaci (Cp) infection has been proposed, and recent reports suggest that doxycycline treatment causes tumor regression in patients with Cp-related OAL. The effectiveness of doxycycline treatment in Cp-negative OAL has not been tested. METHODS In a prospective trial, 27 OAL patients (15 newly diagnosed and 12 ...

OBJECTIVES To evaluate the microbiological cure rate after treatment with tetracyclines or azithromycin in patients infected with M genitalium. METHODS One hundred and fifty-two men and 60 women positive for M genitalium were recruited. Patients treated either with doxycyline for 9 days or with azithromycin 1 g stat. were compared. Those still positive for M genitalium after primary doxycycli...