This paper describes the 5dpo-2000 team. The paper will be divided into three main sections, corresponding to three main blocks: the Global Level, the Local Level and the Interface. These Levels, their subsystems and some implementation details will be described next.

BACKGROUND Preliminary clinical evidence suggests that heme iron polypeptide (HIP) might represent a promising, novel oral iron supplementation strategy in chronic kidney disease. The aim of this multi-centre randomized controlled trial was to determine the ability of HIP administration to augment iron stores in darbepoetin (DPO)-treated patients compared with conventional oral iron supplementa...

BACKGROUND Leptospirosis is a potentially life-threatening but curable zoonosis whose prognosis depends on accurate and timely diagnosis. Because of its non-specific clinical presentation, laboratory testing is essential to confirm the diagnosis. Here, we aimed to assess the performance of two enzyme-linked immunosorbent assays (ELISAs) (ELISA Serion and ELISA-Hb Pasteur) and one immunodot (Gen...

The voltage-gated potassium channel Kv1.5 is one of the key regulators of membrane potential repolarization in human atrial myocytes and is considered a potential drug target to treat atrial fibrillation. In this study we sought to determine molecular mechanism of action of DPO-1, a diphenylphosphine oxide derivative recently shown to terminate experimental atrial arrhythmia without affecting v...

Great efforts are directed towards improving productivity, consistency and quality of biopharmaceutical processes products. One particular area is the development new sensors for continuous monitoring critical bioprocess parameters by using online or in-line systems. Recently, we developed a glucose biosensor applicable in single-use, long-term mammalian cell bioreactors. Now, integrated this s...

Abstract Millions of individuals who have recovered from SARS-CoV-2 infection may be eligible to participate in convalescent plasma donor programs, yet the optimal window for donating high neutralizing titer COVID-19 immunotherapy remains unknown. Here we studied response trajectories antibodies directed surface spike glycoprotein and vitro live virus titers (VN) 175 donors longitudinally sampl...

All food scientists must utilize plants for their application as functional foods to reduce hypercholesterolemia incidence through diet. Canarium odontophyllum (dabai) is a novel source new healthy oil and foods. In this work, we evaluate the hepatoprotective effects of supercritical carbon dioxide (SC-CO2) extracted dabai pulp (DPO) defatted (DDP) against elicited by high-cholesterol diet in r...

Despite drainage, because the pneumothorax was persistent, the patient underwent video-assisted thoracoscopic surgery 2 days later. The lung was particularly ‘‘rigid’’ and lamellar deposits of calcified osteoid material, with marrow elements in the alveolar spaces and interstitium, were found in the lung biopsies (fig. 3). The lung parenchyma was otherwise normal. There was no suggestion of any...

A sharing platform is a digital that facilitates access to underutilized goods by renting or lending them others. Users become less dependent on ownership which improves efficiency, sustainability, and the sense of community. The Sharing Economy (SE) considered complex domain because value co-creation can occur between multiple types users. Developing software offers right functionality for int...