نتایج جستجو برای: dppc

تعداد نتایج: 1101  

Journal: :Journal of applied physiology 2003
Jan Johansson Margareta Some Britt-Marie Linderholm Andreas Almlén Tore Curstedt Bengt Robertson

Available surfactants for treatment of respiratory distress syndrome in newborn infants are derived from animal lungs, which limits supply and poses a danger of propagating infectious material. Poly-Val-->poly-Leu analogs of surfactant protein (SP)-C can be synthesized in large quantities and exhibit surface activity similar to SP-C. Here, activity of synthetic surfactants containing a poly-Leu...

Journal: :Biochimica et biophysica acta 2007
Sukit Leekumjorn Amadeu K Sum

Molecular dynamics simulations were used for a comprehensive study of the structural properties of saturated lipid bilayers, DPPC and DPPE, near the main phase transition. Though the chemical structure of DPPC and DPPE are largely similar (they only differ in the choline and ethanolamine groups), their transformation process from a gel to a liquid-crystalline state is contrasting. For DPPC, thr...

Journal: :Colloids and interfaces 2022

Phospholipids and hyaluronan are two key biomolecules that contribute to the excellent lubrication of articular joints. alone in combination with have also displayed low friction forces on smooth surfaces micro- nanosized tribological contacts. In an effort develop aqueous-based systems, it is highly relevant explore if these types molecules able provide efficient macroscopic contacts involving...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2008
Sandra R Bates Chandra Dodia Jian-Qin Tao Aron B Fisher

Previous studies with the isolated perfused rat lung showed that both clathrin- and actin-mediated pathways are responsible for endocytosis of dipalmitoylphosphatidylcholine (DPPC)-labeled liposomes by granular pneumocytes in the intact lung. Using surfactant protein-A (SP-A) gene-targeted mice, we examined the uptake of [(3)H]DPPC liposomes by isolated mouse lungs under basal and secretagogue-...

Journal: :Biophysical journal 2007
Jacob Sonne Morten Ø Jensen Flemming Y Hansen Lars Hemmingsen Günther H Peters

Molecular dynamics simulations of dipalmitoylphosphatidylcholine (DPPC) lipid bilayers using the CHARMM27 force field in the tensionless isothermal-isobaric (NPT) ensemble give highly ordered, gel-like bilayers with an area per lipid of approximately 48 A(2). To obtain fluid (L(alpha)) phase properties of DPPC bilayers represented by the CHARMM energy function in this ensemble, we reparameteriz...

2016
Keishi Suga Akari Hamasaki Junpei Chinzaka Hiroshi Umakoshi

Cardiolipin (CL) is a phospholipid found in the outer mitochondrial membrane (OMM) and inner mitochondrial membrane (IMM) in animal cells. Isocitrate dehydrogenase (ICDH) is an important catalytic enzyme that is localized at the cytosol and mitochondria; the metabolic pathway catalyzed by ICDH differs between the OMM and IMM. To estimate the possible role of lipid membrane in the enzymatic acti...

Journal: :The journal of physical chemistry. B 2013
Kevin P Armendariz Robert C Dunn

Single molecule fluorescence measurements are used to probe the effects of GM1 in DPPC monolayers. Langmuir-Blodgett films of GM1 and DPPC were doped with ~10(-8) mol % of the fluorescent lipid probe, BODIPY-PC, and transferred onto glass substrates at 23 mN/m. As shown previously, the individual orientation of each BODIPY-PC probe in the membrane can be measured using defocused polarized total...

Journal: :Biochimica et biophysica acta 2008
Grégory Francius Samuel Dufour Magali Deleu Michel Paquot Marie-Paule Mingeot-Leclercq Yves F Dufrêne

We used real-time atomic force microscopy (AFM) to visualize the interactions between supported lipid membranes and well-defined surfactin analogs, with the aim to understand the influence of geometry, charge and hydrophobicity. AFM images of mixed dioleoylphosphatidylcholine/dipalmitoylphosphatidylcholine (DOPC/DPPC) bilayers recorded after injection of cyclic surfactin at 1 mM, i.e. well-abov...

2017
Syed W. H. Shah Christian Schwieger Zheng Li Jörg Kressler Alfred Blume

We studied the interaction of amphiphilic and triphilic polymers with monolayers prepared from F-DPPC (1-palmitoyl-2-(16-fluoropalmitoyl)-sn-glycero-3-phosphocholine), a phospholipid with a single fluorine atom at the terminus of the sn-2 chain, an analogue of dipalmitoyl-phosphatidylcholine (DPPC). The amphiphilic block copolymers contained a hydrophobic poly(propylene oxide) block flanked by ...

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