نتایج جستجو برای: dppc

تعداد نتایج: 1101  

Journal: :Physical chemistry chemical physics : PCCP 2014
Xian Kong Shanshan Qin Diannan Lu Zheng Liu

While the surface tension of a cell membrane, or a plasma membrane, regulates cell functions, little is known about its effect on the conformational changes of the lipid bilayer and hence the resulting changes in the cell membrane. To obtain some insights into the phase transition of the lipid bilayer as a function of surface tension, we used a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)...

Journal: :Journal of colloid and interface science 2009
Jun Yin Ya-Pu Zhao

The polar headgroup of dipalmitoylphosphatidylcholine (DPPC) molecule both in gas phase and aqueous solution is investigated by the hybrid quantum mechanical/molecular mechanical (QM/MM) method, in which the polar head of DPPC molecule and the bound water molecules are treated with density functional theory (DFT), while the apolar hydrocarbon chain of DPPC molecule is treated with MM method. It...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2005
Alex Tonks Joan Parton Amanda J Tonks Roger H K Morris Alison Finall Kenneth P Jones Simon K Jackson

Pulmonary surfactant phospholipids have been shown previously to regulate inflammatory functions of human monocytes. This study was undertaken to delineate the mechanisms by which pulmonary surfactant modulates the respiratory burst in a human monocytic cell line, MonoMac-6 (MM6). Preincubation of MM6 cells with the surfactant preparations Survanta, Curosurf, or Exosurf Neonatal inhibited the o...

Journal: :Antimicrobial agents and chemotherapy 2008
Yoshiko Fukui Keiko Shindoh Yumiko Yamamoto Shin Koyano Isao Kosugi Toyofumi Yamaguchi Ichiro Kurane Naoki Inoue

To simplify the detection of infectious human cytomegalovirus (HCMV), we generated a cell line that produced luciferase in a dose-dependent manner upon HCMV infection. Using this cell line, we identified anti-HCMV compounds from a diverse library of 9,600 compounds. One of them, 1-(3,5-dichloro-4-pyridyl)piperidine-4-carboxamide (DPPC), was effective against HCMV (Towne strain) infection of hum...

Journal: :Langmuir : the ACS journal of surfaces and colloids 2007
Kandice L Harper Heather C Allen

Vibrational sum frequency generation spectroscopy is used to study the interactions of the charged soluble organic surfactant sodium dodecyl sulfate (SDS) with an insoluble 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayer at the air-aqueous interface. Results indicate that the surfactant species compete for surface sites in the mixed system, with a lower monolayer number density of ...

Journal: :The Biochemical journal 1993
C Casals E Miguel J Perez-Gil

The fluorescence characteristics of surfactant protein A (SP-A) from porcine and human bronchoalveolar lavage were determined in the presence and absence of lipids. After excitation at either 275 or 295 nm, the fluorescence emission spectrum of both proteins was characterized by two maxima at about 326 and 337 nm, indicating heterogeneity in the emission of the two tryptophan residues of SP-A, ...

Journal: :Biophysical journal 2004
Antonio Cruz Luis Vázquez Marisela Vélez Jesús Pérez-Gil

Monolayers of dipalmitoylphosphatidylcholine (DPPC) and DPPC/dipalmitoylphosphatidylglycerol (DPPG) (7:3, w/w) in the absence or in the presence of 2, 5, 10, or 20 weight percent of porcine surfactant protein SP-B were spread at the air-liquid interface of a surface balance, compressed up to surface pressures in the liquid-expanded/liquid-condensed (LE-LC) plateau of the isotherm, transferred o...

Journal: :The American journal of physiology 1999
Kaushik Nag James G Munro Kevin Inchley Samuel Schürch Nils O Petersen Fred Possmayer

Pulmonary surfactant stabilizes the alveoli by lining the air-fluid interface with films that reduce surface tension to near 0 mN/m (γmin). Surfactant protein B (SP-B) enhances the surface activity of surfactant phospholipids. A captive bubble tensiometer (CBT) was used to study the properties of adsorbed films of dipalmitoylphosphatidylcholine (DPPC) with acidic 1-palmitoyl-2-oleoyl- sn-glycer...

2014
Davit Hakobyan Andreas Heuer

The lipid mixture of DPPC (saturated lipid)/DUPC (unsaturated lipid)/CHOL (cholesterol) is studied with respect to its ability to form liquid-ordered and liquid-disordered phases. We employ coarse-grained simulations with MARTINI force field. All three components are systematically modified in order to explore the relevant molecular properties, leading to phase separation. Specifically, we show...

Journal: :Biophysical journal 2008
Shelli L Frey Eva Y Chi Cristóbal Arratia Jaroslaw Majewski Kristian Kjaer Ka Yee C Lee

Mixed monolayers of the ganglioside G(M1) and the lipid dipalmitoylphosphatidlycholine (DPPC) at air-water and solid-air interfaces were investigated using various biophysical techniques to ascertain the location and phase behavior of the ganglioside molecules in a mixed membrane. The effects induced by G(M1) on the mean molecular area of the binary mixtures and the phase behavior of DPPC were ...

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