Arterial stiffness and central hemodynamics attract increasing scientific interest within the hypertensive community during the last decade. Accumulating evidence indicates that aortic stiffness is a strong and independent predictor of cardiovascular events and all-cause mortality in hypertensive patients, and its predictive value extends beyond traditional risk factors. The role of central hem...

Poor-insight obsessive-compulsive disorder (PI-OCD) is a severe form of OCD where the 'typically obsessive' features of intrusive, 'egodystonic' feelings and thoughts are absent. PI-OCD is difficult to treat, often requiring very high doses of serotonergic drugs as well as antipsychotic augmentation. When this occurs, unpleasant side effects as nausea are common, eventually further reducing com...

BACKGROUND Rapid eye movement (REM) sleep is greatest in the developing brain, is driven by acetylcholine, and may represent a protected time for neuroplasticity. Recently published data from our lab observed that children with autism spent significantly less time in this state during a single night recording than did typically developing children and those with developmental delay without auti...

INTRODUCTION Restless legs syndrome (RLS) affects 5-15% of adults, but is often unrecognized and consequently misdiagnosed. The International Restless Legs Scale (IRLS) has been developed and validated to assess the severity of RLS. Currently, the most common treatment for RLS is levodopa, but this may lead to augmentation of symptoms. Pramipexole has been developed as an alternative treatment ...

The use of cheaper and recyclable biomaterials (like eggshells) to synthesize high purity hydroxyapatite (HAp) with better properties (small particle size, large surface area and pore volume) for applications (in environmental remediation, bone augmentation and replacement, and drug delivery systems) is vital since high-purity synthetic calcium sources are expensive. In this work, pure and meso...

Background: Research on treatment of depression has raised concerns regarding adequacy of medication trials and rationality of drug choice. Little data exists regarding pharmacotherapy by psychiatric residents. As practice habits begun in training will likely persist after graduation, examination of residents' antidepressant use may ultimately improve treatment by psychiatrists. Methods: Charts...

Drug-drug interactions (DDIs) could lead to various unexpected adverse consequences, so-called DDI events. Predicting events can reduce the potential risk of combinatorial therapy and improve safety medication use, has attracted much attention in deep learning community. Recently, graph neural network (GNN)-based models have aroused broad interest achieved satisfactory results event prediction....

The city of Staufen im Breisgau in southwest Germany suffers from a localized land uplift, which has occurred in the past six years in relation to geothermal drilling activities in 2007. So far, severe damages at 269 buildings have been recorded. The chemical transformation of anhydrite and water to gypsum, resulting in a volume increase, has been attributed as the cause of the uplift. Previous...

DESCRIPTION Capsular contracture is a common complication following breast augmentation. Although the etiology is unknown, it is hypothesized that subclinical infection contributes to the process. Surgical treatment strategies must take this into account to avoid recurrence.