A novel data augmentation method suitable for wearable sensor data is proposed. Although numerous studies have revealed the importance of the data augmentation to improve the accuracy and robustness in machine-learning tasks, the data augmentation method that is applicable to wearable sensor data have not been well studied. Unlike the conventional data augmentation methods, which are mainly dev...

BACKGROUND A large, multicenter, 10-year observational study is being conducted to compare the long-term safety and effectiveness of Natrelle silicone breast implants with saline implants or national norms. Study baseline data and surgical characteristics are reported here. METHODS Women seeking primary augmentation, revision-augmentation, primary reconstruction, or revision-reconstruction pa...

Although monoaminergic antidepressants revolutionized the treatment of Major Depressive Disorder (MDD) over a half-century ago, approximately one third of depressed patients experience treatment-resistant depression (TRD). Such patients account for a disproportionately large burden of disease, as evidenced by increased disability, cost, human suffering, and suicide. This review addresses the de...

Aortic augmentation index, a measure of central systolic blood pressure augmentation arising mainly from pressure-wave reflection, increases with vascular aging. The augmentation index is influenced by aortic pulse-wave velocity (related to aortic stiffness) and by the site and extent of wave reflection. To clarify the relative influence of pulse-wave velocity and wave reflection on the augment...

Recent pre-clinical and clinical studies have examined the potential use of anti-glucocorticoid drug augmentation - including glucocorticoid receptor (GR) antagonists - as a method of improving treatment response in severe psychiatric illness. However, the direct and persistent effects such drugs exert on the hypothalamic-pituitary-adrenal (HPA) axis are unclear. We examined afternoon cortisol ...

Simple, safe and effective permeability enhancers are crucial for successful non-invasive drug delivery methods. We seek local permeability augmentation mechanisms for integration into passive or active architectures in order to enable novel therapeutic delivery routes of the target drug while minimizing drug formulation challenges. This study explores the efficacy of hydrogen peroxide (HP) as ...

T umescent local anesthesia was first described by Klein in 1987 when he detailed the infiltration of large volumes of a diluted solution of lidocaine with epinephrine into fat before liposuction. The tumescent technique revolutionized liposuction by eliminating the necessity of general anesthesia or intravenous sedation and the copious bleeding that had been associated with liposuction procedu...

BACKGROUND Breast augmentation with subglandular versus subpectoral implants may differentially impact the early detection of breast cancer and treatment recommendations. The authors assessed the impact of prior augmentation on the diagnosis and management of breast cancer in women undergoing mastectomy. METHODS Breast cancer diagnosis and management were retrospectively analyzed in all women...

Global Navigation Satellite (GPS) system has gradually come of age and has found itself a place as standard Navigation equipment in most aircraft. However, data from a GPS Receiver is not reliable enough for it to be used as a primary or sole source of navigation information. As a result GPS only system is allowed to be used only as a supplemental means of navigation for aircraft in the less cr...