The majority of depressed patients do not experience sufficient response to their initial antidepressant medication. Augmentation strategies, particularly the use of atypical antipsychotics to augment selective serotonin reuptake inhibitors (SSRIs), have proliferated over the last 15 years, and 2 atypical antipsychotics, aripiprazole and quetiapine, have received US Food and Drug Administration...

tiated by a psychiatrist.” Aripiprazole and quetiapine are both approved by the US Food and Drug Administration for augmentation pharmacotherapy of major depressive disorder. Given a shortage of psychiatrists, and wait times of up to 3 months to see a psychiatrist, and in an age when psychiatric disorders are the leading source of medical disability, it is imperative for primary care physicians...

Jérôme Lacan Université de Toulouse; ISAE CNRS; LAAS [email protected] Emmanuel Lochin Université de Toulouse; ISAE CNRS; LAAS [email protected] Pierre-Ugo Tournoux Université de Toulouse; ISAE CNRS; LAAS [email protected] Amine Bouabdallah Université de Toulouse; ISAE CNRS; LAAS [email protected] Vincent Roca INRIA Rhône-Alpes Planète research team [email protected]

The present importance of breast augmentation (BA) is shown by year-on-year increases: with 8439 augmentations performed by BAAPS members in 2007 the UK still lags America where 307,000 were performed. Having survived an almost hysterical media reaction to perceived silicone health risks in the 1990s, a growing body of evidence attests to the demonstrable benefits of BA. Improved implant design...

Primary hypersomnia, a rare clinical syndrome, was diagnosed in a 14-year-old boy. The syndrome showed partial response to high dose fluoxetine therapy (120 mg/day) which recruited insomnia, an adverse effect of the drug, for therapeutic purposes. Response was enhanced with intermittent methylphenidate in association with a lower dose of fluoxetine. A possible pharmacokinetic interaction develo...

Background According to the American Psychiatric Association practice guidelines, if a patient with Major Depressive Disorder (MDD) has not responded or achieved only a partial response after 4-8 weeks of therapy, a dose change, switch to a new drug, or augmentation therapy is recommended [1]. Combined use of standard antidepressants with dopaminergic agents and psychostimulants can lead to acc...

Sir: Despite the marked progress in the pharmacologic treatment of obsessive-compulsive disorder (OCD)—especially with high doses of serotonin reuptake inhibitors (SRIs), alone or in combination with low doses of antipsychotics—a substantial proportion of patients fail to respond to it. In such cases, an augmentation tactic with drugs from other chemical classes, including antiepileptic drugs, ...

BACKGROUND Excessively high reoperation rates in breast augmentation premarket approval studies are a major concern of patients and the U.S. Food and Drug Administration. Over the past two decades, reoperation rates have remained between 13 and 20 percent at 3 years in three different premarket approval studies for three different types of implant devices, indicating that high reoperation rates...

Augmentation of deficient and atrophic alveolar ridges is an important aspect of dental implant therapy with the goal of providing a functional restoration in harmony with adjacent natural dentition. Bone splitting technique is considered a distinguished augmentation method for treatment of deficient alveolar ridges. According to this procedure, the compromised alveolar ridge is opened from the...