Renal Catabolism of Recombinant Human Soluble CD4 after Intravenous Administration to Male Sprague-Dawley Rats. TIMOThY W. HEPBURN, CHARLES B. DAVIS, JAMES J. URBANSKI, BRIAN R. SMITh, WILLIAM H. SCHAEFER, MICHAEL A. CARBONARO, AND PETER J. BUGELSKI 1044 Metabolism of Mofarotene in Hepatocytes and Liver Microsomes from Different Species: Comparison with in Vivo Data and Evaluation of the Cytoch...

Submit Manuscript | http://medcraveonline.com Abbreviations: AhR: Aryl Hydrocarbon Receptor; Arnt: Nuclear Translocator; CLP: Cecal Ligation and Puncture; CVB3: Coxsackievirus B3; CRP: C-Reactive Protein; CYP-450: Cytochrome P-450; ECOD: Ethoxycoumarin O-Deethylase; GH: Growth Hormone; IMND: Imipramine N-Demethylase; iNOS: inducible Nitric Oxide Synthetase; icv: intracerebroventricularly; IFN-γ...

Ethnicity is an important demographic variable contributing to interindividual variability in drug metabolism and response. In this rapidly expanding research area many genetic factors that account for the effects of ethnicity on pharmacokinetics, pharmacodynamics, and drug safety have been identified. This review focuses on recent developments that have improved understanding of the molecular ...

Although pregnancy is known to cause changes in drug pharmacokinetics, little is known about its impact on serum levels of antipsychotics. In this study we retrospectively assessed 201 routine serum antipsychotic therapeutic drug monitoring concentration measurements obtained from a total of 110 pregnancies in 103 women, and 512 measurements from the same women before and after pregnancy. Serum...

The SLC22 family of transporters is mostly composed non-selective transporters, which are expressed highly in liver, kidney and intestine, playing a major role drug disposition. may be divided into three subfamilies based on the nature substrate transported: organic cations (OCTs), anions (OATs) zwiterrion/cations (OCTN). Membrane topology predicted to contain 12 TM domains with intracellular t...

Genki Minegishia, Yasuhiro Kazukibc, Shin-Ichiro Nittad, Atsushi Miyajimae, Hidetaka Akitaa & Kaoru Kobayashie*a Laboratory of DDS Design and Drug Disposition, Graduate School Pharmaceutical Sciences, Chiba University, Chiba, Japanb Chromosome Engineering Research Center (CERC), Tottori Tottori, Japanc Department Molecular Cellular Biology, Division Genome Functions, Faculty Medicine, Life Scie...

This article revisits the old controversy concerning the relation of the mother’s brother and sister’s son in patrilineal societies in the light both of anthropological criticisms of the very notion of kinship and of evolutionary and epidemiological approaches to culture. It argues that the ritualized patterns of behavior discussed by Radcliffe-Brown, Goody, and others are to be explained in te...

Five studies examined whether, in self-control dilemmas, individuals develop an implicit disposition to approach goals and avoid temptations, psychologically as well as physically. Using a method developed by A. K. Solarz (1960; see also K. L. Duckworth, J. A. Bargh, M. Garcia, & S. Chaiken, 2002), the authors assessed the time for pulling and pushing a lever in response to goal- and temptation...

The positive trend in volunteering among the Dutch young old may in part be due to a relatively favorable disposition to volunteer. Using data from the Longitudinal Aging Study Amsterdam, volunteering rates of 55-64 year olds in 1992 and 2002 were compared and associated with (among others) three types of dispositional factors: religious involvement, age-related engagement norms, and parental s...