Background. Recent data suggest a role for H19 gene in promoting cancer transformation and progression. Cervical cancer, progresses from high-grade lesions (CIN3). At present, it is unclear if CIN lesions express H19. Objectives. To determine H19 expression in patient samples of CIN3 as well as the ability of a construct in which the promoter from the H19 gene drives expression of the diphtheri...

The sleep disorder narcolepsy results from loss of hypothalamic orexin/hypocretin neurons. Although narcolepsy onset is usually postpubertal, current mouse models involve loss of either orexin peptides or orexin neurons from birth. To create a model of orexin/hypocretin deficiency with closer fidelity to human narcolepsy, diphtheria toxin A (DTA) was expressed in orexin neurons under control of...

the kinetics of molybdenite oxidation was studied by non-isothermal tga-dta with heating rate 5 ºc.min-1.the model-fitting kinetic approach applied to tga data .the coats-redfern method used for model fitting. the popular model-fitting gives excellent fit for non-isothermal data in chemically controlled regime. the apparent activation energy was determined to be about 34.2 kcalmol-1 with pre-ex...

BACKGROUND Congestive states can be identified and managed through algorithms such as the Diuretic Treatment Algorithm (DTA) to adjust the diuretic over the telephone, focused on the clinical evaluation. However, the DTA is currently available only in English. OBJECTIVE To adapt the DTA and test its applicability for Brazil in outpatients with heart failure. METHODS The stages of translatio...

Surgical extent-of-resection has been shown to have an impact on high-grade glioma (HGG) outcomes; however, complete resection is rarely achievable in difficult-to-access (DTA) tumors. Controlled thermal damage to the tumor may have the same impact in DTA-HGGs. We report our multicenter results of laser interstitial thermal therapy (LITT) in DTA-HGGs. We retrospectively reviewed 34 consecutive ...

Abstract Next-generation sequencing (NGS)-based measurable residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML) is widely applicable and prognostic prior to allogeneic hematopoietic cell transplantation (alloHCT). We evaluated the role of clonal hematopoiesis–associated DNMT3A, TET2, ASXL1 (DTA) non-DTA mutations for MRD post-alloHCT refine marker selection. Of 154 AM...

As a necessary process of modern drug development, finding compound that can selectively bind to specific protein is highly challenging and costly. Exploring drug-target interaction strength in terms affinity (DTA) an emerging effective research approach for development. However, it model interactions deep learning manner, few studies provide interpretable analysis models. This paper proposes D...

The present work investigates equilibrium conditions and dissociation enthalpy of hydrates formed from CO2-TBAB(tetra-n-butylammonium bromide)-water mixtures. Differential Thermal Analysis (DTA) was used for Hydrate-Liquid-Vapour (H-L-V) equilibrium condition determination in a TBAB concentration range from 4.43 to 9.01 wt% and in a CO2 pressure range from 0.3 to 2.5 MPa. The results showed tha...

The paper presents the calibration and application of a simulation-based dynamic traffic assignment (DTA) model on a portion of the City of Calgary road network in Alberta, Canada. The DTA model iteratively re-assigns flow to paths using the Method of Successive Averages (MSA), based on travel times obtained with a traffic simulation model. The original sub-network extracted from a regional pla...

OBJECTIVES To explain methods for data synthesis of evidence from diagnostic test accuracy (DTA) studies, and to illustrate different types of analyses that may be performed in a DTA systematic review. METHODS We described properties of meta-analytic methods for quantitative synthesis of evidence. We used a DTA review comparing the accuracy of three screening questionnaires for bipolar disord...