background: reduced bioavailability of nitric oxide (no) and the t?786c polymorphism of endothelial nitric oxide synthase (enos) gene have been reported as risk factors for the development of coronary artery disease (cad) with conflicting results. we investigated the association of plasma no levels, t?786c genetic polymorphism, and gene expression levels of enos with cad risk in an iranian subp...

background: preeclampsia is a pregnancy complication with unknown etiology and its incidence is associated with genetic and environmental factors. there are inconsistent reports related to the role of endothelial nitric oxide synthase (enos) 4a/b polymorphism on the risk of preeclampsia development. the aim of the present study was to investigate the possible influence of enos 4a/b and its syne...

Endothelial Nitric Oxide Synthase (eNOS) produces nitric oxide (NO) from L-arginine and is important for the maintenance of cardiovascular homeostasis. Congestive heart failure (CHF) generally results in increased pulmonary blood flow and if untreated leads to pulmonary hypertension and end stage heart failure. We therefore hypothesized that increased pulmonary flow without changes in pres...

background: variants in the candidate genes enos, cyp11b2 and ace have been implicated as liable biomarkers that can predict complications like hypertension and preeclampsia. studies on the impact and distribution of these variants on healthy pregnancy have not been done so far in south indian or in any of the native indian population. examining these variants could lay a strong basis in unders...

O objetivo desta pesquisa é analisar as anomalias de chuva a partir do Índice Anomalia Chuva (IAC) e sua relação ao fenômeno El Niño Oscilação-Sul (ENOS), no Município Viçosa-MG, através dados pluviométricos período 1925 2018. A estatística descritiva revelou que estação seca ocorre inverno (abril setembro) chuvosa verão (outubro março), sendo os meses mais secos junho, julho agosto. aplicação ...

Type 2 diabetes mellitus (T2D) is a significant global public health problem that has seen substantial increase in the number of affected individuals recent decades. In murine model T2D (db/db), we found several abnormalities, including aberrant intracellular calcium concentration ([Ca2+]i), decreased glucose transport, increased production reactive oxygen species (ROS), elevated levels pro-inf...

Endothelial dysfunction, with impaired bioavailability and/or bioactivity of the vasoprotective molecule, nitric oxide, appears to be a vital step in initiation atherosclerosis. Several studies have shown that dietary nitrate/nitrite can significant benefits on human cardiovascular homeostasis. Although serum nitrite concentrations reach micromolar levels, physiological significance normal tiss...