We describe two sets of epitopes present in HLA-DP molecules; they were identified with alloantibodies from clinical serum samples. Specificity was determined using fluorescent beads coated with single antigens and detected in a Luminex platform. Of the patients with anti-HLA class II antibodies, 18% had anti-DP antibodies; among these, 24 of 32 patients (75%) had antibodies against the dimorph...

The folate receptor (FR) is expressed in many tumor types, among those ovarian and lung cancer. Due to the high FR affinity of folic acid, it has been used for targeting of FR-positive tumors, allowing specific delivery of attached probes to the malignant tissue. Therefore, nuclear imaging of FR-positive cancer is of clinical interest for selecting patients who could benefit from innovative the...

BACKGROUND For an optimal care of patients in home healthcare, it is essential to exchange healthcare-related information with other stakeholders. Unfortunately, paper-based documentation procedures as well as the heterogeneity between information systems inhibit a well-regulated communication. Therefore, a digital patient care record is introduced to establish the foundation for integrating he...

Transverse-field μSR shifts and relaxation rates have been measured in the non-Fermi liquid (NFL) alloy system UCu5−xPtx, x = 1.0, 1.5, and 2.5. At low temperatures the fractional spread in Knight shifts δK/K ≈ δχ/χ is & 2 for x = 1, but is only half this value for x = 1.5 and 2.5. In a disorder-driven scenario where the NFL behavior is due to a broadly distributed (Kondo or Griffiths-phase clu...

Multielectron ionization and Coulomb explosion of methane clusters (CA4)n, A ) H, D, and T, in very intense (I ) 1018-1019 W cm-2) laser fields were studied using classical dynamics simulations. The products of Coulomb explosion involve light A+ ions (p, d, and t nuclei) with energies up to 20 keV, C4+ ions at I ) 1018 W cm-2, and C6+ ions (carbon nuclei) with energies up to 110 keV at I ) 1019...

The rapid development of omic technologies facilitate cancer researchers to apply multiple genomic technologies simultaneously. In fact, the complex nature of cancer biology is the reason why we need tools for data integration. Given the complexity of managing multiple technologies and dataset formats, several projects have been introduced including cancer Biomedical Informatics Grid (caGRID) a...

A number of viruses have the capacity to cross the placenta and infect the fetus to cause, among other potential outcomes, developmental defects (teratogenesis), fetal death and abortion. Bluetongue virus (BTV) infection of fetal ruminants provides an excellent model for the study of virus-induced teratogenesis. This model has shown that only viruses modified by passage in cell culture, such as...

A cross sectional study was conducted among military armoured vehicle drivers in the two largest mechanized battalions with the objective to determine the prevalence of low back pain (LBP), and its association with whole body vibration (WBV) and other associated factors. A self-administered questionnaire and Human Vibration Meter were used in this study. A total of 159 respondents participated ...

TRAF family member-associated NF-κB activator (TANK) is a negative regulator of canonical NF-κB signaling in the Toll-like receptor (TLR)and B-cell receptor (BLR)-mediated signaling pathways. However, functions of TANK in viral infection-mediated NF-κB activation remain unclear. Here we reported that TANK was cleaved by encephalomyocarditis virus (EMCV) 3C at the 197 and 291 glutamine residues,...

Biomedical research on human subjects often requires a large amount of data to be collected by personal interviews, Internet based questionnaires, lab measurements or by extracting data from paper or electronic health records. This data needs to be stored, analyzed and interpreted in a comprehensive manner. There is a great need for user-friendly software systems that allow to design and launch...