Ebola virus is one of the most deadly pathogens known to infect humans. The current Ebola outbreak in West Africa is unprecedented in magnitude and duration and, as of November 30, 2014, shows no signs of abating. For the first time, cases of Ebola virus disease have been diagnosed in the US, originating from patients who traveled during the incubation period. The outbreak has generated worldwi...

The Indian health minister, Jagat Prakash Nadda, has formed a committee with officials from the ministries of health, civil aviation, and immigration to check that all airports in the country are adhering to guidelines on quarantining people with suspected Ebola virus disease. The committee will report to the government in a week. A statement from the government said that Nadda emphasised the i...

Despite its isolation three decades ago, Ebola virus continues to cause periodic outbreaks of severe hemorrhagic fever in humans, and the closely related Marburg virus is responsible for a recent outbreak of disease in Angola. The mortality rate associated with Ebola virus infection can reach 90 percent, and so the prospect of an effective therapy is attractive. A recent study by Chandran et al. 1

1. World Health Organization. Eighth Meeting of the WHO Advisory Group on the EVD Response; 2015 Mar 20; Geneva. Geneva: The Organization; 2015 [cited 2015 Mar 25]. http://www.who.int/ csr/disease/ebola/advisory-groups/8th-meeting-report.pdf?ua=1 2. World Health Organization. WHO Statement on the Meeting of the International Health Regulations Emergency Committee Regarding the 2014 Ebola Outbre...

Cytotoxic T lymphocytes (CTLs) are proposed to be critical for protection from intracellular pathogens such as Ebola virus. However, there have been no demonstrations that protection against Ebola virus is mediated by Ebola virus-specific CTLs. Here, we report that C57BL/6 mice vaccinated with Venezuelan equine encephalitis virus replicons encoding the Ebola virus nucleoprotein (NP) survived le...

Existing mouse models of lethal Ebola virus infection do not reproduce hallmark symptoms of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated intravascular coagulation nor death from shock, thus restricting pathogenesis studies to nonhuman primates. Here we show that mice from the Collaborative Cross panel of recombinant inbred mice exhibit distinct disease phenotypes ...

Ebola virus (EBOV), of the family Filoviridae viruses, is a NIAID category A, lethal human pathogen. It is responsible for causing Ebola virus disease (EVD) that is a severe hemorrhagic fever and has a cumulative death rate of 41% in the ongoing epidemic in West Africa. There is an ever-increasing need to consolidate and make available all the knowledge that we possess on EBOV, even if it is co...

The ongoing Ebola virus disease (Ebola) epidemic in West Africa, like previous Ebola outbreaks, has been characterized by amplification in health care settings and increased risk for health care workers (HCWs), who often do not have access to appropriate personal protective equipment. In many locations, Ebola treatment units (ETUs) have been established to optimize care of patients with Ebola w...

Sporadic outbreaks of Ebola virus infection have been documented since the mid-Seventies and viral exposure can lead to lethal haemorrhagic fever with case fatalities as high as 90%. There is now a comprehensive body of data from both ongoing and completed clinical trials assessing various vaccine strategies, which were rapidly advanced through clinical trials in response to the 2013-2016 Ebola...