ebola is one of the members of filoviruses family. it causes severe hemorrhagic with the human mortality rate of 50-90%. in the initial steps of infection, it enters the host cell by glyco protein1 (gp1). gp1 is a big subunit with the molecular weight of 130 kda. its n-terminal domain is responsible for attaching the host cell. in the present study, a database containing 100.000 drug like chemi...

We have produced a new Ebola virus pseudotype, E-S-FLU, that can be handled in biosafety level 1/2 containment for laboratory analysis. The E-S-FLU virus is a single-cycle influenza virus coated with Ebolavirus glycoprotein, and it encodes enhanced green fluorescence protein as a reporter that replaces the influenza virus hemagglutinin. MDCK-SIAT1 cells were transduced to express Ebolavirus gly...

The polymerase inhibitor favipiravir is a candidate for the treatment of Ebola virus disease. Here, we designed a mathematical model to characterize the viral dynamics in 20 mice experimentally infected with Ebola virus, which were either left untreated or treated with favipiravir at 6 or 8days post infection. This approach provided estimates of kinetic parameters of Ebola virus reproduction, s...

ince early March 2014, >20,000 probable and suspect addresses considerations for pregnant women with epidemiS cases of Ebola virus disease (EVD) have been reported in Guinea, Sierra Leone, and Liberia, with more than 8000 deaths reported as of Jan. 4, 2015. Although pregnancy data are limited, reports of pregnant women with EVD in this and previous outbreaks describe very high maternal, fetal, ...

BACKGROUND In March, 2016, a flare-up of Ebola virus disease was reported in Guinea, and in response ring vaccination with the unlicensed rVSV-ZEBOV vaccine was introduced under expanded access, the first time that an Ebola vaccine has been used in an outbreak setting outside a clinical trial. Here we describe the safety of rVSV-ZEBOV candidate vaccine and operational feasibility of ring vaccin...

Ebola virus disease (EVD), previously named as Ebola haemorrhagic fever, is often a highly fatal illness (1). The disease occurs in outbreaks mostly in Sub-Saharan Africa and the largest of the outbreaks is the ongoing 2014 West Africa Ebola outbreak. The disease has a mortality rate of upto 90% and so far 1711 cases & 932 deaths (till 6 Aug, 2014) have been reported in four African countries (...

OBJECTIVES The Ebola epidemic has received extensive media coverage since the first diagnosed cases of the virus in the US. We investigated risk perceptions of Ebola among individuals living in the US and measured their knowledge of the virus. METHOD US residents completed an online survey (conducted 14-18 November 2014) that assessed their Ebola knowledge and risk perceptions. RESULTS Resp...

SUMMARY Since Ebola virus was discovered in 1970s, the virus has persisted in Africa and sporadic fatal outbreaks in humans and non-human primates have been reported. However, the evolutionary history of Ebola virus remains unclear. In this study, 27 Ebola virus strains with complete glycoprotein genes, including five species (Zaire, Sudan, Reston, Tai Forest, Bundibugyo), were analysed. Here, ...