The ongoing Ebola virus outbreak in West Africa has highlighted questions regarding stability of the virus and detection of RNA from corpses. We used Ebola virus-infected macaques to model humans who died of Ebola virus disease. Viable virus was isolated <7 days posteuthanasia; viral RNA was detectable for 10 weeks.

Dear Editor-in-Chief The present global consideration is on the recent outbreak of 2014 Western Ebola virus in West Africa (1 – 3). This viral hemorrhagic fever wide spreads to several countries in West Africa and remote countries (1 - 3). With high death rate, the disease is presently on the list of public health threatens. The main problem for management of the infection is the limited knowl...

The 2014 outbreak of Ebola virus disease (EVD) in West Africa, caused by Ebola virus (Zaire Ebola virus species), is the largest outbreak of EVD in history. It cause hemorrhagic fever in human and nonhuman primates with high mortality rate up to 90% and can be transmitted by direct contact with blood, body fluids, skin of EVD patients or persons who have died of EVD. As of December 17, 2014, 45...

The aim of this article is to review and update the pathophysiological mechanisms and clinical aspects of the Ebola virus disease including the novel therapeutic measures. Ebola virus, a RNA virus, was discovered in 1976 as “ Zaire ebolavirus “ and currently is responsible for outbreak in the west Africa. The mucin-liked region of the Ebola virus envelope play a significant role in viral infect...

Ebola virus is known to persist in semen of male survivors of Ebola virus disease (EVD). However, maximum duration of, or risk factors for, virus persistence are unknown. We report an EVD survivor with preexisting HIV infection, whose semen was positive for Ebola virus RNA 565 days after recovery from EVD.

TFiloviruses particularly Ebola and Marburg viruses causes deadly hemorrhagic fevers in humans and non-human primates particularly the great apes (chimpanzees and gorillas). Ebola virus disease (EVD), which is also known as Ebola hemorrhagic fever (EHF) is caused by Ebola virus, which has a case fatality rate of up to 90% [1-3]. Ebola virus is among the most dangerous microorganisms today. It h...

In December 2014, Ebola virus disease (EVD) was diagnosed in a healthcare worker in the United Kingdom after the worker returned from an Ebola treatment center in Sierra Leone. The worker flew on 2 flights during the early stages of disease. Follow-up of 238 contacts showed no evidence of secondary transmission of Ebola virus.

The Ebola virus was identified in 1976 during epidemics of haemorrhagic fever in southern Sudan and northern Zaire (now the Democratic Republic of the Congo). The average mortality rate of Ebola virus disease, formerly known as Ebola haemorrhagic fever, is around 50% with rates varying from 25-90% in past outbreaks. The chronology of the outbreaks of the disease in different countries since 197...

Ebola virus infections cause a deadly hemorrhagic disease for which no vaccines or therapeutics has received regulatory approval. Here we show isolation of three (Q206, Q314 and Q411) neutralizing monoclonal antibodies (mAbs) against the surface glycoprotein (GP) of Ebola virus identified in West Africa in 2014 through sequential immunization of Chinese rhesus macaques and antigen-specific sing...