The elevated plus maze test is a rodent model of anxiety that is used extensively in the discovery of novel anxiolytic agents and to investigate the psychological and neurochemical basis of anxiety. The model is based on Montgomery's 1 observation that rats spent less time exploring the 'open' arms of a novel 'Y'-shaped elevated maze than an enclosed arm. The elevated plus maze used today 2 is ...

The aim of this study is to evaluate the effects of pravastatin on Adriamycin (ADR)-induced nephropathy and the mechanisms involved. Forty rats were divided into the following 4 groups: control, ADR (15 mg.kg-1, IP), ADR plus pravastatin (20 mg.kg-1 which was started 5 days prior to ADR injection), and ADR plus pravastatin (20 mg.kg-1 which was started 5 days after ADR injection). On day 20 aft...

α-Galycoceramide (α-Galcer) or the common name of krn7000 is an α-gelasphin derivative. The α-Galcer structure consists of a galactose combined with a ceramide in an α-configuration. Social isolation (SI) has been linked with enhanced inflammation, through modifications in transcriptional pathways linked with glucocorticoid, to stress. Our hypothesis is to investigate mediatory role of glucocor...

introduction: effective perception of fear signals is crucial for organism survival. when threated, the organism indicates defensive behaviors. methods: elevated plus–maze has high efficiency for measurement of fear behavior and is widly used for fear behavior determination. increase in two parameters percent of openarm entries (%oae) and percent of time spent in the open-arm (%oat) in the elev...

HIGHLIGHTS: Tumor progression and anxiety depression behaviors under evaluation during propranolol use in murine melanoma. Evaluation of through forced swimming behavior tests, elevated plus maze, open field marble-burying test.

The aim of this study is to evaluate the effects of pravastatin on Adriamycin (ADR)-induced nephropathy and the mechanisms involved. Forty rats were divided into the following 4 groups: control, ADR (15 mg.kg-1, IP), ADR plus pravastatin (20 mg.kg-1 which was started 5 days prior to ADR injection), and ADR plus pravastatin (20 mg.kg-1 which was started 5 days after ADR injection). On day 20 aft...