نتایج جستجو برای: elevated plus maze

تعداد نتایج: 290006  

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 1998
S L Blatt R N Takahashi

Post-training intracerebroventricular administration of procaine (20 micrograms/microliter) and dimethocaine (10 or 20 micrograms/microliter), local anesthetics of the ester class, prolonged the latency (s) in the retention test of male and female 3-month-old Swiss albino mice (25-35 g body weight; N = 140) in the elevated plus-maze (mean +/- SEM for 10 male mice: control = 41.2 +/- 8.1; procai...

Journal: :Behavioural brain research 2011
Andrea Milena Becerra Garcia Fernando P Cardenas Silvio Morato

The so-called anxiolytic and anxiogenic drugs are considered to cause, respectively, increases and decreases in plus-maze open arm exploration, without modifying locomotor activity occurring in the closed arms in an elevated plus-maze when the animals are tested in an illuminated environment. Simply testing animals in the dark also increases open arm exploration, which may be interpreted as an ...

Journal: :European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2010
K S Sink K N Segovia J Sink P A Randall L E Collins M Correa E J Markus V K Vemuri A Makriyannis J D Salamone

Cannabinoid CB1 inverse agonists suppress food-motivated behaviors, but may also induce psychiatric effects such as depression and anxiety. To evaluate behaviors potentially related to anxiety, the present experiments assessed the CB1 inverse agonist AM251 (2.0-8.0mg/kg), the CB1 antagonist AM4113 (3.0-12.0mg/kg), and the benzodiazepine inverse agonist FG-7142 (10.0-20.0mg/kg), using the open f...

Journal: :Behavioural brain research 1998
G Liebsch A Montkowski F Holsboer R Landgraf

Over the past years, two breeding lines, derived originally from outbred Wistar rats, have been established that differ markedly and consistently in their anxiety-related behaviour in the elevated plus-maze. At the age of ten weeks, rats were tested once on the elevated plus-maze and the males and females displaying the most anxious and the least anxious behaviour were sib-mated to start a new ...

Journal: :Polish journal of pharmacology 2003
Mehmet Kurt S Sirri Bilge Osman Kukula Suleyman Celik Yuksel Kesim

The present study was performed to investigate the effect of propofol on anxiety using the elevated plus-maze test. Groups of mice received propofol (20, 40, 60 mg/kg) or diazepam (2 mg/kg), caffeine (30 mg/kg), L-arginine (100 mg/kg), m-chlorophenylpiperazine (m-CPP, 2.5 mg/kg) and then were placed in an elevated plus-maze that was composed of two opposite closed arms and two opposite open arm...

2014
Kumar S Janardan Sharma

Background: Epilepsy is one of the most prevalent non-communicable neurologic diseases leading to significant disability and mortality. Complaints of impaired learning and memory are common in patients of epilepsy. Antiepileptic drugs (AEDs) may further enhance this impairment. So the present study was carried out on albino rats to evaluate the effect of AEDs on learning and memory. Objective: ...

2014
Foyet Harquin Simplice Tsala David Emery Ngatanko Abaissou Hervé Hervé

We evaluated the anxiolytic and antidepressant effects of the aqueous extract of the bark of Tapinanthus dodoneifolius (TAE) (Danser) (25, 50, and 100 mg/kg), using open field, elevated plus maze, and forced swimming tests. Effect of TAE was compared to standard drugs diazepam (2 mg/kg) and imipramine (10 mg/kg). Additionally, the same doses of TAE were evaluated on rat's memory using Y-maze ta...

Journal: :Behavioural processes 2007
S Botelho C Estanislau S Morato

The present work investigated whether the number of rats housed in a cage affects exploration of an elevated plus-maze. Male Wistar-derived rats were kept 1, 2, 3, 4, 6, 8, 12, 16, or 24 to same size cages either for 1 or 14 days and tested in the elevated plus-maze. Rats kept 6 to a cage were arbitrarily considered controls because this is the housing condition adopted in many laboratories, ou...

Journal: :Anesthesiology 2011
Arvind Palanisamy Mark G Baxter Pamela K Keel Zhongcong Xie Gregory Crosby Deborah J Culley

BACKGROUND Preclinical evidence suggests that commonly used anesthetic agents induce long-lasting neurobehavioral changes when administered early in life, but there has been virtually no attention to the neurodevelopmental consequences for the fetus of maternal anesthesia. This study tested the hypothesis that fetal rats exposed to isoflurane during maternal anesthesia on gestational day 14, wh...

2010
VASUDEVAN MANI MILIND PARLE KALAVATHY RAMASAMY ABU BAKAR ABDUL MAJEED

Daucus carota Linn. commonly known as “carrot" belongs to the family Apiaceae (Umbelliferae) and is cultivated almost all over the world as a useful vegetable. Carrot is widely consumed as an aphrodisiac and nervine tonic and its scraped root is used as a local stimulant for indolent ulcers. In light of the above, the present study was undertaken to investigate the effects of D. carota seeds on...

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