We studied the impact of α-synuclein overexpression in brainstem serotonin neurons using a novel vector construct where the expression of human wildtype α-synuclein is driven by the tryptophan hydroxylase promoter, allowing expression of α-synuclein at elevated levels, and with high selectivity, in serotonergic neurons. α-Synuclein induced degenerative changes in axons and dendrites, displaying...

The effect of two supplements containing resveratrol (“Resveratrol” and “Enoant”) on the psycho-emotional state animals with an initial index anxiety depression above 0.5 was studied. For this, “Elevated plus maze” (EPM) “Forced swim test” (FST) were used. “Resveratrol” significantly reduces depressivity (ID) in males 7th 14th days application, females – only day. No significant influence (AI) ...

The methanolic leaf extract of Thuja occidentalis was evaluated for possible sedative activities in mice. Sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping time and elevated-plus maze (EPM) tests at 200mg/kg and 400 mg/kg.  The extract decreased the locomotor activity of mice in hole cross, open field and EPM test and showed the remarka...

The effects of kindling of the right anterior medial amygdala of Wistar rats was studied. Kindling lastingly increased anxiety (decreased open-arm exploration) in the elevated plus-maze 1 week after the last kindled seizure, replicating previous findings. Changes in anxiety were independent of changes in exploration or activity in either the plus-maze or hole board. A new finding is the depende...

Abstract: Aim: Lead is a powerful metal which induced neurotoxicity through the degradation of neurons in body. Various neuronal changes have shown correlation with generation free radicals and oxidative stress. The present study was carried out to evaluate neuroprotective activity Natrium diethyl dithiocarbamate trihydrate (NDDCT) on lead neurodegeneration rat’s model. Methods: We evaluated ND...

Ethnopharmacological relevance: Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae) is a medicinal plant known for its anxiolytic, antidepressant and anticonvulsant activities in Cameroonian folk medicine. Aim of the study: The aim this work to evaluate anxiolytic effects aqueous extracts investigate mechanism action. Materials methods: Elevated plus maze test open field were u...