BACKGROUND Medications are frequently prescribed outside their regulatory approval (off-label) by physicians particularly where appropriate therapies are not available. However, the risk/benefit ratio of drugs in off-label use needs to be critically appraised because it may differ from approved on-label usage. Therefore, an extensive exploration of current evidence on clinical data is well-advi...

The evaluation of innovation from early to late phase studies requires appropriate selection and reporting of outcomes. These are well defined for pharmaceutical interventions, but much less well considered for nonpharmaceutical interventions such as surgery. We report a new method an evolution review to understand and document the evolution of outcomes reported at each stage of evaluation of n...

As stakeholders vie for increasingly limited resources in health care, physicians would be well advised to hone their skills of negotiation. Negotiation is defined as a strategy to resolve a divergence of interests, be they real or perceived, where common interests also exist. Negotiation requires effective communication of goals, needs, and wants. The “basic needs” model of negotiation is best...

Background: The challenges facing the implementation of telehealth services are to successfully integrate the health care system and make an integral part of clinical routine. Yet, a large proportion of telehealth projects barely survive beyond the pilot stage. For most of these projects, it appears that the citizens are rarely consulted about its needs and expectations regarding telehealth ser...

s read and 136 found to be relevant 2056 Abstracts identified 1680 Pubmed 1313 Embase 141 Cochrane Methodology Register 126 MathSciNet Papers obtained and read in full Did they present a trial design for evaluating markers for treatment selection?