OBJECTIVE To assess the value of routine screening of nuclear status of day-2 four-cell preembryos for single embryo transfer (SET) in predicting implantation. DESIGN Retrospective analysis. SETTING Private IVF unit. PATIENT(S) A total of 1,985 fresh embryo transfers on day 2 or day 3 were performed from January 2002 to November 2004. In 1,295 (65.2%) of these transfers, SET was performed...

Although progress was made in in vitro fertilization (IVF) techniques, the majority of embryos transferred fail to implant. Morphology embryo scoring is the standard procedure for most of IVF centres for choosing the best embryo, but remains limited since even the embryos classified as "top quality" may not implant. As it has been shown that i) CD146 is involved in embryo implantation and ii) m...

Background: Garbhasambhav Samugri is a concept in Ayurveda which describes factors to bring healthy offspring into the society. The kshetra one of four essential for formation and development embryo, term used grossly women but specifically garbhashaya (uterus). According modern science, embryo implants endometrial lining uterus. All components endometrium undergo cyclic changes called as cycle...

Background: Embryo implantation is a complex biological process which requires synchronized dialogue between the receptive endometrium and blastocyst. The endometrium, however, only to embryo for very short period. Recurrent failure (RIF) major challenge in assisted reproductive techniques mainly due impaired receptivity, but there still need reliable valid clinical test assess endometrial rece...

Background -Recurrent pregnancy loss defined as two or more miscarriage before 20 weeks of pregnancy affecting 1-5 % or women in reproductive age .There are many etiologies have been suggested, like Genetic, Immunologic, Thrombophila, Endocrine and Anatomic; but in 50% of cases, the exact etiology remains uncertain. Endometrium acts as biosensor of embryo quality and endometrium itself contribu...

Imprinted genes are essential for fetal development, growth regulation, and postnatal behavior. However, little is known about imprinted genes in livestock. We hypothesized that certain putatively imprinted genes affected normal peri-implantation development such as embryo elongation, initial placental development, and preparation of implantation. The objective of the present study was to inves...

STUDY QUESTION Does vascular endothelial growth factor (VEGF) have important roles during early embryo development and implantation? SUMMARY ANSWER VEGF plays key roles during mouse preimplantation embryo development, with beneficial effects on time to cavitation, blastocyst cell number and outgrowth, as well as implantation rate and fetal limb development. WHAT IS KNOWN ALREADY Embryo impl...

During embryo implantation, the blastocyst interacts with and regulates the endometrium, and endometrial fluid secreted by the endometrial epithelium nurtures the embryo. Here, we propose that maternal microRNAs (miRNAs) might act as transcriptomic modifier of the pre-implantation embryo. Microarray profiling revealed that six of 27 specific, maternal miRNAs were differentially expressed in the...

OBJECTIVE In this study, we aimed to evaluate the influence of autologous cumulus oocyte complex (COC) coculture on embryonic development and quality, and investigate the implantation and pregnancy rates after cumulus-aided embryo transfer in the ICSI-ET cycles. MATERIAL AND METHODS Ninety five consecutive infertile women undergoing their first cycle of IVF teratment were included in the stud...

Mucin 1 (Muc1) is an integral transmembrane mucin glycoprotein expressed on the apical surface of most epithelia. It is considered to be a barrier to the regulation of embryo implantation by inhibiting attachment of the embryo to the endometrium. Therefore, loss of Muc1 on the surface of uterine epithelial cells is necessary for embryo implantation. Studies have demonstrated that microRNAs (miR...