Background: Endocrine Disrupting Chemicals (EDCs) would cause alterations in organs/systems of exposed individuals or their progeny. Objetive: To identify and analyze the main published findings on effects exposure to EDCs teeth, cartilage, bone. Material Methods: Two databases were analyzed: Medline Web Science. Only observational studies analyzing effect mineralized tissues since 2006 include...

Submit Manuscript | http://medcraveonline.com Abbreviations: AMH: Anti-Mullerian Hormone; AR: Androgen Receptors; ATF3: Activating Transcription Factor 3; CPAs: Congenital Penile Anomalies; CWH: Chordee Without Hypospadias; EDCs: Endocrine Disrupting Chemicals; KFS: Klinefelter Syndrome; LUTS: Lower Urinary Tract Symptoms; MAGPI: Meatal Advancement and Glanuloplasty Incorporated; SMR: Split Med...

BACKGROUND Laboratory and human studies raise concerns about endocrine disruption and asthma resulting from exposure to chemicals in consumer products. Limited labeling or testing information is available to evaluate products as exposure sources. OBJECTIVES We analytically quantified endocrine disruptors and asthma-related chemicals in a range of cosmetics, personal care products, cleaners, s...

Workers and fence-line communities have been the first to benefit from the substantial reductions in toxic chemical use and byproducts in industrial production resulting from the Massachusetts Toxics Use Reduction Act (TURA). As TURA motivates reformulation of products as well as retooling of production processes, benefits could extend more broadly to large-scale reductions in everyday exposure...

BACKGROUND Sex hormones closely regulate development of the male genital organs during fetal life. The hypothesis that xenobiotics may disrupt endogenous hormonal signalling has received considerable scientific attention, but human evidence is scarce. OBJECTIVES We analyse occurrence of hypospadias and cryptorchidism according to maternal and paternal occupational exposure to possible endocri...

At the request of the U.S. Environmental Protection Agency (EPA) Office of Research and Development, a subcommittee of the Board of Scientific Counselors Executive Committee conducted an independent and open peer review of the Endocrine Disrupting Chemicals Research Program (EDC Research Program) of the U.S. EPA. The subcommittee was charged with reviewing the design, relevance, progress, scien...

Birds have been used as model species in ecotoxicological research for decades but have only recently been included in toxicity testing schemes. However, the avian fauna is very diverse. Given this diversity, the ecology, behavior, and reproduction should be considered when selecting the appropriate bird model in ecotoxicological studies. This article focusses on choosing the right bird model s...

BACKGROUND Endocrine-disrupting chemicals (EDCs) influence the activity of estrogen receptors (ERs) and alter the function of the endocrine system. However, the diversity of EDC effects and mechanisms of action are poorly understood. OBJECTIVES We examined the agonistic activity of EDCs through ERα and ERβ. We also investigated the effects of EDCs on ER-mediated target genes. METHODS HepG2 ...

In this study, microwave-assisted extraction (MAE) followed by gas chromatography (GC)-mass spectrometry (MS) analysis has been successfully developed for the simultaneous extraction and determination of contrasting endocrine disrupting chemicals (EDCs) including 17beta-estradiol, estrone, 17(alpha-ethynylestradiol, 16alpha-hydroxyestrone, 4-nonylphenol, 4-tert-octylphenol and bisphenol A in ri...

Endocrine-disrupting chemicals (EDCs) are increasingly prevalent in the environment and the evidence demonstrates that they affect reproductive health, has been accumulating for the last few decades. In this review of recent literature, we present evidence of the effects of estrogen-mimicking EDCs on female reproductive health especially the ovaries and uteri. As representative EDCs, data from ...