BACKGROUND: Chronic endometritis is a clinical and morphological syndrome in which, due to persistent endometrial damage the endometrium by an infectious agent, multiple secondary morphofunctional changes occur that impair cyclic transformation receptivity of uterine mucosa.
 AIM: This study aimed reveal features patients with atrophic chronic impaired hemodynamics endometrium.
 MATER...

background: there are some controversial data on application of progesterone and progesterone plus estrogen at luteal phase. objective: to investigate the effects of different luteal support hormones on the alkaline phosphates (alp) activity in the endometrial epithelium and endometrial thickness during superovulation process for obtaining the optimized endometrial receptivity in animal model. ...

background: reviewing the literature reveals that pentoxifylline (ptx) plus tocopherol (vitamin e) are used mainly to promote sperm quality. however trials focusing on the effects of these drugs in female partner are limited. combination of pentoxifylline and vitamin e appeared to improve the pregnancy rate in patients with a thin endometrium by increasing the endometrial thickness and improvin...

BACKGROUND Reproductive failure, determined as recurrent spontaneous abortions (RSA) or recurrent implantation failure (RIF) in women is not well understood. Several factors, including embryo quality, and cellular and molecular changes in endometrium may contribute to the insufficient feto-maternal interaction resulting in reproductive failure. Prior clinical studies suggest an inadequate endom...

Objective: To determine the messenger RNA and protein expression, as well as distribution of estrogen receptors (ER) and progesterone receptors (PR) in the endocervix compared with the endometrium. Setting: Volunteers in an academic research environment Materials and methods: Twelve volunteer patients undergoing total hysterectomy for benign indications. Patients did not receive any hormonal or...

Considerable evidence supports a role for matrix metalloproteinases (MMP) in menstruation, but their focal pattern of expression within perimenstrual and menstrual endometrium suggests local rather than hormonal regulation. Menstruation shares a number of features with inflammatory responses, with leukocyte infiltration, proliferation and activation, occurring in the endometrium prior to menstr...

INTRODUCTION This study was to evaluate the effectiveness of PRP in the therapy of infertile women with thin endometrium (≤ 7 mm). MATERIAL AND METHODS Five women undergoing in vitro fertilization (IVF) with poor endometrial response still had thin endometrium (< 7 mm) after standard hormone replacement therapy (HRT) and had to cancel embryo transfer cycle. In addition to HRT, intrauterine in...

The endometrium plays a central role among the reproductive tissues in the context of early embryo-maternal communication and pregnancy. This study investigated transcriptome profiles of endometrium samples from day 18 pregnant vs non-pregnant heifers to get insight into the molecular mechanisms involved in conditioning the endometrium for embryo attachment and implantation. Using a combination...

Abnormal endometrial expression of CC-chemokine receptor-1 (CCR1) may play a role in the pathogenesis of endometriosis. Adenomyosis, also called endometriosis interna, occurs when the endometrium invades the myometrium. The objective of this study was to determine CCR1 expression in endometrium in women with adenomyosis as compared to women without adenomyosis. We evaluated endometrial mRNA and...

BACKGROUND Endometriosis is a highly prevalent, benign disease in which the angiogenic, fibrinolytic and metalloproteinase (MMP) systems may be implicated. The objective of this study is to analyse mRNA expression and protein levels of several angiogenic factors and to correlate them with several components of the fibrinolytic and MMP systems in samples from 71 women with endometriosis and 50 c...