Sodium-glucose cotransporter 2 inhibitors offer cardiovascular and renal benefits in patients with chronic kidney disease through not yet clearly defined mechanisms. Juni et al. showed that sodium-glucose inhibitor empagliflozin exposure vitro can restore cardiomyocyte function by counteracting harmful effects of uremic serum on the endothelium-cardiomyocyte crosstalk between endothelial cells ...

The coronavirus infection, COVID-19, caused by SARS-CoV-2 is associated not only with a wide range of respiratory syndromes, but also pronounced destructive effect on the blood vessels whole body. Age and concomitant pathology predispose to more severe course disease. Endothelial damage, widespread vasculitis thrombosis can be distinguished as general nonspecific pathomorphological changes deve...

Diabetic kidney disease (DKD) has become a global health concern, with about 40% of people living type 1 and 2 diabetes mellitus developing DKD. Upregulation vascular endothelial growth factor (VEGF) in the is significant pathology DKD associated increased glomerular permeability. To date, however, current anti-VEGF therapies have demonstrated limited success treating Recent studies shown that ...

The purpose of the study was to analyze professional literature sources devoted influence homocysteine on development vascular disorders. role as a biomarker pathology is considered. Materials and methods. Bibliosemantic analytical methods were used in study. analysis specialized (47 sources) carried out using information scientific-metric databases MEDLINE/PubMed, Scopus Google Scholar. Result...

The purposes of the present study were to examine the natural course of the impairment of endothelium-dependent relaxations during a regeneration and tissue repair process after balloon endothelium removal and to elucidate the cellular mechanism(s) underlying it. Twenty-three male Yorkshire pigs underwent balloon endothelium removal along the proximal portion of either the left anterior descend...