We review below published studies of endothelium-dependent vasodilation in vivo. Endothelium-dependent vasodilation has been demonstrated in conduit arteries in vivo and in the cerebral, coronary, mesenteric, and femoral vascular beds as well as in the microcirculation of the brain and the microcirculation of cremaster muscle. The available evidence, although not complete, strongly suggests tha...

The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial fluid and proteins, and is an important point of entry for leukocytes and tumor cells. The traditional view that lymphatic capillaries are passive participants in these tasks is currently being challenged. This overview highlights recent advances in our understanding of the molecular mechanisms underly...

CD146 is an endothelial junctional adhesion molecule, which expression increased in human glomerular diseases. However, the pathological significance of this overexpression remains unknown. Induction glomerulonephritis mice, by using nephrotoxic serum, showed that was highly induced within damaged glomeruli and associated with renal inflammation fibrosis. Interestingly, 2 weeks after induction,...

Current treatment for corneal endothelial dysfunction consists in the replacement of endothelium by keratoplasty. Owing to scarcity donor corneas and increasing number transplants, alternative treatments such as cell-based therapies are necessary. In this article, we highlight biological aspects cornea endothelium, well context that surrounds need new alternatives conventional We then review so...

BACKGROUND The direct action of sevoflurane on systemic resistance arteries is not fully understood. METHODS Isometric force was recorded in isolated rat small mesenteric arteries. RESULTS Sevoflurane (2-5%) enhanced contractile response to norepinephrine only in the presence of endothelium, but inhibited it in its absence. Sevoflurane still enhanced the norepinephrine response after inhibi...

purpose: to report a case of anterior segment eye deposits in a patient on long-term chlorpromazine therapy. case report: a 34 years old man had been on chlorpromazine therapy for 5 years with a total dose of 1,100 gram. since one year ago, he presented with gradual onset of decreased visual acuity in both eyes. slit-lamp examination revealed multiple fine yellow-brown deposits on the corneal e...

A modified bioassay system was designed to demonstrate the diffusible nature of endothelium-derived contracting factor(s) released by acetylcholine in the aorta of spontaneously hypertensive rat. In "sandwich"-like layered preparation, isometric tension was recorded from a bioassay strip (without endothelium) in the presence of N(G)-nitro-L-arginine and tetrahydrobiopterin to selectively potent...

The endothelium not only mediates relaxation but is a source of contracting factors. Endothelium-dependent contractions are elicited by physical and chemical stimuli (i.e., hypoxia, pressure, and stretch) and autacoids, local and circulating hormones. The mechanism of endothelium-dependent contractions to hypoxia involves withdrawal of nitric oxide. The endothelial cyclooxygenase pathway can pr...

BACKGROUND Vascular abnormalities are a major cause of postoperative complications in irradiated tissues. Endothelial cell dysfunction characterized by diminished endothelium-dependent relaxation may be involved. We examined the endothelium-dependent relaxation and morphology of the endothelium in irradiated human cervical arteries. METHODS AND RESULTS Irradiated arteries were taken from the ...

To study the mechanism of decreased endothelium-dependent relaxations in spontaneously hypertensive rats (SHR), rings of thoracic aorta with and without endothelium were taken from age-matched male SHR and normotensive Wistar-Kyoto rats (WKY) and suspended for isometric tension recording. Acetylcholine caused endothelium-dependent contractions in quiescent rings from SHR but not in those from W...