The present article investigates the effect of tobacco smoking on functional state vascular endothelium in healthy young people without other risk factors for coronary heart disease and arterial hypertension. Based analysis results obtained by rheoplethysmography, endothelium-dependent endothelium-independent responses according to Celermajer D.S.(1992) were studied. increase pulse blood flow r...

the hypotensive effect of garlic has been well-documented in human subjects and animals. since endothelial activity regulates vascular reactivity in physiological and pathophysiological conditions, the aim of the present study was to investigate the effect of garlic on endothelium-dependent and independent relaxation of rat aorta for elucidation of mechanism of the garlic anti-hypertensive effe...

artemisia species, growing in almost all the northern hemisphere, is used in folk medicine of some countries as a remedy for hypertension. since some cardiovascular disorders including hypertension are accompanied with altered responsiveness of vascular alpha-adrenergic receptors, the effect of aqueous artemisia annua extract (100 and 200 mg kg-1) on a1-adrenoceptor agonist-induced contraction ...

purpose: to report the confocal microscopic features of endothelial vacuolation in donated corneas and to confirm the observed changes by transmission electron microscopy. methods: confocal and transmission electron microscopy were performed on donated corneas with endothelial vacuole formation on slitlamp biomicroscopy. the ultrastructural findings were also compared with those of a normal-loo...

objective(s) diabetes related dysfunction of resistance vessels is associated with vascular occlusive diseases. vasorelaxant agents may have a role in control of diabetic cardiovascular complications. gamma aminobutyric acid (gaba) has demonstrated to cause vasorelaxation. the present study was designed to determine i) the vasorelaxatory effect of gaba on diabetic vessels and ii) the role of en...

in this study we investigated the effects of endothelium removal and l-name on responses to α-adrenoceptor agonists. male wistar rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. rings of arteries 3-4 mm in length were cut from each vessel and then mounted in 10 ml isolated organ bath, bathed in krebs maintained at 37°c...

the purpose of the work presented here was to investigate endotheliumdependent relaxations in the rabbit coronary ligation model of heart failure. we investigated endothelium-dependent relaxations at the level of larger vessels (thoracic aorta and vena cava left renal artery and left renal vein lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal ear v...

Background and Objective: Cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. In this study, the effect of chronic administration of Tribulus terrestris (TT) feeding was studied on aortic reactivity of streptozotocin (STZ)-diabetic rats and some underlying mechanisms were investigated.    Materials and Methods: Male diabetic rats receive...

to evaluate the acute effect of lovastatin on diabetic endothelial dysfunction, we examined this effect on the aortic rings of streptozotocin-diabetic rats. the endothelial function was assessed in aortic rings isolated from diabetic rats, 12 weeks after treatment with streptozotocin (45 mg/kg, i.p.). the concentration-response curve to acetylcholine (ach) in the aortic rings precontracted with...

the present study was undertaken to determine whether two-month treatment of streptozotocin (stz)-diabetic rats with aqueous leaf extract of trigonella foenum-graecum (tfg 200 mg/kg i.p.) could improve thoracic aortic responsiveness and to evaluate its endothelium dependency. for this purpose, vascular responses to kcl and noradrenaline (na) were measured. diabetic state significantly increased...