Summary The gut microbiota affects remote organ functions but its impact on organotypic endothelial cell (EC) transcriptomes remains unexplored. liver endothelium encounters microbiota-derived signals and metabolites via the portal circulation. To pinpoint how commensals affect hepatic sinusoidal endothelium, a magnetic sorting protocol, combined with fluorescence-activated sorting, wa...

angiotensin ii is a major endocrine hormone that affects directly both vascular smooth muscle and endothelial cells. since vascular reactivity to angiotensin ii changes in more physiological and pathophysiological conditions, the present study was performed to investigate the effect of intraperitoneal administration of angiotensin-converting enzyme inhibitor and captopril (30 and 50 mg kg-1, on...

In this study we investigated the effects of endothelium removal and L-NAME on responses to α-adrenoceptor agonists. Male Wistar rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. Rings of arteries 3-4 mm in length were cut from each vessel and then mounted in 10 mL isolated organ bath, bathed in Krebs maintained at ...

Mechanotargeting of Atherogenic Endothelium In article number 202300137, Pouria Fattahi, Sulin Zhang, Peter J. Butler, and colleagues provide direct evidence for cell mechanics-based targeting nanoparticles (NPs) to atherogenic endothelium, a drug-delivery strategy termed, mechanotargeting. Microcontact-patterned adhesive islands induce endothelial cells adopt prescribed morphologies that mimic...

Background. Homocysteine is a sulfur-containing amino acid that can have damaging effect on the vascular endothelium, being an independent risk factor for development of cardiovascular pathology. The purpose. To evaluate functional state endothelium in hyperhomocysteinemia children with arterial hypertension. Material and methods. 111 aged 14 to 18 years were examined. All patients divided into...

cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. in this study, the effect of chronic administration of sesame (sesamum indicum l) seed feeding was studied on aortic reactivity of streptozotocin (stz)-diabetic rats. male diabetic rats received sesame seed-mixed food at weight ratios of 3% and 6% for 7 weeks, one week after diabetes in...

objective(s): angiotensin ⅱ type 1 receptor blockers (arbs) represent one of the widely used antihypertensive agents. in addition to anti-hypertension effect, some arbs also show other molecular effects such as activating peroxisome proliferator-activated receptor-γ and so on. here we studied the effects of telmisartan on the rat isolated mesenteric artery rings pre-contracted by phenylephrine ...

The internal mammary artery (IMA) is currently the preferred conduit for myocardial revascularization. However, pre-operative vasospasm and a hypoperfusion state during maximal exercise may limit its use as a bypass graft. The mechanism of spasm has not been clearly defined. Since β-adrenoceptor activation plays a major role in vasorelaxation, the present study was carried out to investigate th...

Objective: In a previous work, we showed that asafoetida essential oil (AEO), from oleo-gum resin of Ferula asafoetida L. from the Apiaceae family, has a vasodilatory effect. This effect was both endothelium-dependent and endothelium-independent. The present study was designed to determine whether potassium channels and intracellular calcium release contribute to AEO-i...