compared to L-IS (n 18, p 0.02) but no difference in total cell count; all other cell types, including epithelial and squamous cells, were not significantly different between the two collections. E-IS and BAL eosinophils were significantly correlated (n 20, 0.72, p 0.0004) in all groups and in asthma alone (n 10, 0.82, p 0.004); L-IS showed weaker correlations for percentage of eosinophils with...

Background Making decision on asthma as an inflammatory disease is done mostly on the airways function and the patient symptoms which most of them are nonspecific and subjective. Also, the children are not able to express their signs and collaboration in examination of the lungs function. Evaluation of serum level inflammatory biomarkers can be useful in assessment of the response to treatment ...

In this study the routine use of different parameters for evaluation of the overall therapeutic outcome in atopic dermatitis was investigated. The disease activity of 117 randomly selected hospitalized patients suffering from atopic dermatitis was routinely assessed using the Severity Scoring of Atopic Dermatitis (SCORAD) index on admission and at discharge. Serum levels of eosinophil cationic ...

BACKGROUND The objective was to characterise the process and consequences of eosinophil activation and lysis in patients with chronic eosinophilic pneumonia and to compare them with those in patients with eosinophil pulmonary infiltrates from other causes. METHODS Cells from bronchoalveolar lavage fluid of four patients with chronic eosinophilic pneumonia and four patients with eosinophilic i...

Studies have shown that eosinophils are closely related to pathogenesis of bronchial asthma. Eosinophils release eosinophil cationic protein (ECP), which plays an important role in infection and allergic reactions. Serum ECP mRNA expression in children with bronchial asthma has not been adequately investigated. We analyzed serum ECP mRNA expression in 63 children with bronchial asthma and 21 he...

The large specific granule of the human eosinophil contains a number of low molecular weight, highly basic proteins that have been purified to homogeneity, including the major basic protein (MBP) (1-3), 1 the eosinophil cationic protein (4, 5), and the eosinophil-derived neurotoxin (6, 7). The comparative physicochemical and immunochemical characteristics of these proteins have been examined in...

This study evaluated peripheral eosinophil and serum eosinophilic cationic protein (s-ECP) levels as markers of asthma control. A total of 38 children with asthma (16 controlled and 22 partially controlled) were compared with 16 age- and sex-matched healthy children. Total asthma cases had higher eosinophil counts and s-ECP levels than healthy children and partially controlled asthmatics had si...

The article deals with the clinical value of monitoring serum eosinophil cationic protein (ECP) in patients with allergic diseases, especially bronchial asthma in paediatric practice. We confirmed the seasonal increase of serum ECP level in group of patients with bronchial asthma especially with higher total IgE level.

The large specific granule of the human eosinophil contains a number of low molecular weight, highly basic proteins that have been purified to homogeneity, including the major basic protein (MBP) (1-3), 1 the eosinophil cationic protein (4, 5), and the eosinophil-derived neurotoxin (6, 7). The comparative physicochemical and immunochemical characteristics of these proteins have been examined in...