Homozygous mice overexpressing Claudin-6 (Cldn6) exhibit a perturbation in the epidermal differentiation program leading to a defective epidermal permeability barrier (EPB) and dehydration induced death ensuing within 48 h of birth [Turksen, K., Troy, T.C., 2002. Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Development 129, 1775-1784]. Their heterozygous counter...

We report a direct folding study of seven helical proteins (, Trpcage, , C34, N36, , ) ranging from 17 to 53 amino acids through standard molecular dynamics simulations using a recently developed polarizable force field-Effective Polarizable Bond (EPB) method. The backbone RMSDs, radius of gyrations, native contacts and native helix content are in good agreement with the experimental results. C...

Abstract Prediction of equatorial plasma bubbles (EPBs) continues to be a challenge for the scientific community. We present novel data analysis approach, employed on collocated radar and ionosonde observations from Gadanki, providing new experimental results characterizing overhead upwelling bottomside F layer linking it EPB formation. Using this approach we propose parameter based predict occ...

Plasma is the component of blood from which lead is free to cross cell membranes and cause organ toxicity. Plasma lead levels, however, are extremely low and difficult to measure. Urinary lead originates from plasma lead that has been filtered at the glomerular level; thus, urinary lead adjusted for glomerular filtration rate serves as a proxy for plasma lead levels. In this investigation we ex...

INTRODUCTION Beijing subway line 14 includes four stations and approximately 2.8 km of tunnels between the Dongfengbeiqiao and Jingshunlu areas of the city. Due to the surface and underground space limitations of this section, a double-track running tunnel instead of two single-track running tunnels was adopted to connect the two stations. The double-track tunnels were excavated by a 10.22 m di...

Abstract Background Most inflammatory bowel disease (IBD) patients are unable to maintain long-term remission by current treatment. Propionate has been proven be able exert anti-inflammatory effects in intestinal inflammation, but direct supplement of propionate actual disadvantages including low bioavailability and poor sustained effect, et. al. Methods In this study, the genes related acetate...

Abstract Ionospheric structure is characterized by the space–time variation of electron density. However, our understanding physical processes that initiate and sustain intermediate-scale development does not relate directly to statistical measures characterize structure. Consequently, high-resolution physics-based equatorial plasma bubble simulations are essential for identifying systematic re...