OBJECTIVE To validate glomerular filtration rate (GFR) estimating equations in white HIV-infected patients based on serum creatinine and/or serum cystatin C. DESIGN Single-center, cross-sectional evaluation of the predictive performance of GFR estimators. METHODS GFR was measured by iohexol plasma clearance. Serum creatinine (Scr) and serum cystatin C (Scyst) were measured by traceable and ...

OBJECTIVES The goal of this work was to reduce the scan time of contrast-enhanced whole-heart coronary magnetic resonance angiography (MRA) by using a gradient echo interleaved echo planar imaging (GRE-EPI) sequence at 3 T field strength. MATERIALS AND METHODS A GRE-EPI sequence was optimized to acquire contrast-enhanced whole-heart coronary MRA at 3 T. First-order phase correction was used f...

Fig. 1: General scheme for spin echo based SER-EPI sequence: The standard SER-scheme is extended not only by the refocusing 180 RF-pulse but also by a gradient pulse in phase-encoding direction. This gradient prephasing pulse aligns the gradient echo with the spin echo of the first excitation pulse s1. Fig.2: k-space data of spin-echo based SER-EPI sequence: Phase-encode direction is top to bot...

Introduction Geometric distortions in Echo Planar Imaging (EPI) are dependent on two sequence parameters: the phase encoding FOV and the echo spacing between two consecutive ky lines, both of which affect the k-space traversal speed. Assuming that a maximum readout gradient bandwidth is used, the echo spacing can be reduced by decreasing the resolution in the kx (not ky!) direction. Both Short ...

Epirubicin (EPI), an anthracycline antitumour antibiotic, is a known intercalating and DNA damaging agent. Here, we study the molecular interaction of EPI with histones and other cellular targets. EPI binding with histone core protein was predicted with spectroscopic and computational techniques. The molecular distance r, between donor (histone H3) and acceptor (EPI) was estimated using Förster...

We have reported earlier that immunodepletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation (DIC) induced by infusing a low concentration of tissue factor (TF). We now describe the effect of immunodepletion of EPI in rabbits administered endotoxin. Cortisone-treated rabbits were administered anti-rabbit EPI immunoglobulin (IgG) or Fab fragment...

An assay was standardized to measure extrinsic pathway inhibitor (EPI) activity in human plasma. Variables that could potentially influence its measurement were systematically examined. The coefficient of variation of the assay was 6.3% for the same sample assayed on different days. The linear regression line for a plot of observed v expected values of mixtures of plasmas with different EPI lev...

Speed has always been a critical consideration in magnetic resonance imaging (MRI), promising dramatic gains in imaging speed, a reduction in motion and susceptibility artifacts, and ultimately increased throughput for clinical studies. In the context of functional magnetic resonance imaging (fMRI), MRI pulse sequences designed to increase the speed and spatial resolution have always been a top...

Introduction: The development of diffusion-weighted imaging (DWI) of the spine has been hindered by the large off-resonance effects problematic for single-shot EPI. Overcoming these restrictions would open up applications ranging from the diagnosis of spinal cord infarction, vertebral body fractures, lymphoma, trauma, and many other disorders. Navigated interleaved EPI has been shown to overcom...

Epiberberine (EPI) is a novel and potentially effective therapeutic and preventive agent for diabetes and cardiovascular disease. To evaluate its potential value for drug development, a specific, sensitive and robust high-performance liquid chromatography-tandem mass spectrometry assay for the determination of EPI in rat biological samples was established. This assay was used to study the pharm...