Numerous studies have suggested that epinephrine may facilitate neural release of NE. There have been no studies in humans that demonstrate the functional significance of this action. To determine whether epinephrine facilitates neurogenic vasoconstriction in humans, we contrasted forearm vasoconstrictor responses to a reflex stimulus (lower body negative pressure [LBNP]) and to intraarterial N...

The use of epinephrine in septic shock remains controversial. Nevertheless, epinephrine is widely used around the world and the reported morbidity and mortality rates with it are no different from those observed with other vasopressors. In volunteers, epinephrine increases heart rate, mean arterial pressure and cardiac output. Epinephrine also induces hyperglycemia and hyperlactatemia. In hyper...

Endogenous epinephrine has been found to increase alveolar liquid clearance (ALC) in several pulmonary edema models. In this study, we infused epinephrine intravenously for 1 h in anesthetized rats to produce plasma epinephrine concentrations commonly observed in this species under stressful conditions and measured ALC by mass balance. Epinephrine increased ALC from 31.5 +/- 3.2 to 48.9 +/- 1.1...

Epinephrine infusion into the portal vein produced rapid changes in the activities of certain hepatic, epididymal fat, and skeletal muscle glycolytic enzymes and fructose diphosphatase in the rat. Epinephrine produced a rapid increase in hepatic, epididymal fat, and skeletal muscle fructose diphosphatase activity. In contrast, epinephrine produced a rapid decrease in hepatic phosphofructokinase...

BACKGROUND Food allergy is the most common cause of anaphylaxis outside the hospital setting. OBJECTIVE We sought to determine the rate, circumstances, and risk factors for repeated doses of epinephrine in the treatment of food-induced anaphylaxis in children. METHODS Anonymous questionnaires were distributed to families of children with food allergies during allergy outpatient visits to a ...

Epinephrine Epinephrine hydrochloride produces beneficial effects in patients during cardiac arrest, primarily because of its a-adrenergic receptor–stimulating properties.1 The adrenergic effects of epinephrine increase myocardial and cerebral blood flow during CPR.2 The value and safety of the b-adrenergic effects of epinephrine are controversial because they may increase myocardial work and r...

In a previous publication (l), evidence was presented indicating that a major pathway of epinephrine metabolism involved cleavage of the molecule at some point between the P-carbon and the methyl carbon. The presence of ether-soluble substances in urine suggested that methylamine was split off, at least to some extent. A minimum of five urinary metabolites of epinephrine has been revealed by pa...