Several lines of evidence suggest a psychophysiological link between stress, adrenomedullary activation, and the genesis of hypertension. Experimental data support four important concepts: 1) epinephrine stimulates prejunctional ft-adrenergic receptors that facilitate norepinephrine release from sympathetic nerve endings; 2) epinephrine can be converted into a cotransmitter by neuronal uptake a...

To test the hypothesis that glycemic sensitivity to epinephrine is reduced in older individuals and to assess the impact of a sedentary lifestyle on responses to the hormone, we performed 30-min sequential intravenous infusions of epinephrine (0, 41, 82, 164, 246, and 328 pmol ⋅ kg-1 ⋅ min-1) in young ( n = 10) and older ( n = 23) healthy subjects. We performed these again after 12 mo of physic...

In a previous publication (l), evidence was presented indicating that a major pathway of epinephrine metabolism involved cleavage of the molecule at some point between the P-carbon and the methyl carbon. The presence of ether-soluble substances in urine suggested that methylamine was split off, at least to some extent. A minimum of five urinary metabolites of epinephrine has been revealed by pa...

BACKGROUND Vasopressin is an alternative to epinephrine for vasopressor therapy during cardiopulmonary resuscitation, but clinical experience with this treatment has been limited. METHODS We randomly assigned adults who had had an out-of-hospital cardiac arrest to receive two injections of either 40 IU of vasopressin or 1 mg of epinephrine, followed by additional treatment with epinephrine if...

Epinephrine Epinephrine hydrochloride produces beneficial effects in patients during cardiac arrest, primarily because of its a-adrenergic receptor–stimulating properties.1 The adrenergic effects of epinephrine increase myocardial and cerebral blood flow during CPR.2 The value and safety of the b-adrenergic effects of epinephrine are controversial because they may increase myocardial work and r...

Stress-induced hormones can alter the inflammatory response to tissue injury; however, the precise mechanism by which epinephrine influences inflammatory response and wound healing is not well defined. Here we demonstrate that epinephrine alters the neutrophil (polymorphonuclear leukocyte (PMN))-dependent inflammatory response to a cutaneous wound. Using noninvasive real-time imaging of genetic...

Epinephrine Epinephrine hydrochloride produces beneficial effects in patients during cardiac arrest, primarily because of its a-adrenergic receptor–stimulating properties.1 The adrenergic effects of epinephrine increase myocardial and cerebral blood flow during CPR.2 The value and safety of the b-adrenergic effects of epinephrine are controversial because they may increase myocardial work and r...

Epinephrine Epinephrine hydrochloride produces beneficial effects in patients during cardiac arrest, primarily because of its a-adrenergic receptor–stimulating properties.1 The adrenergic effects of epinephrine increase myocardial and cerebral blood flow during CPR.2 The value and safety of the b-adrenergic effects of epinephrine are controversial because they may increase myocardial work and r...

Epinephrine Epinephrine hydrochloride produces beneficial effects in patients during cardiac arrest, primarily because of its a-adrenergic receptor–stimulating properties.1 The adrenergic effects of epinephrine increase myocardial and cerebral blood flow during CPR.2 The value and safety of the b-adrenergic effects of epinephrine are controversial because they may increase myocardial work and r...

Epinephrine Epinephrine hydrochloride produces beneficial effects in patients during cardiac arrest, primarily because of its a-adrenergic receptor–stimulating properties.1 The adrenergic effects of epinephrine increase myocardial and cerebral blood flow during CPR.2 The value and safety of the b-adrenergic effects of epinephrine are controversial because they may increase myocardial work and r...