BACKGROUND The purpose of this study was to investigate the effects of vasopressin versus epinephrine, and both drugs combined, in a porcine model of simulated adult asphyxial cardiac arrest. METHODS AND RESULTS At approximately 7 minutes after the endotracheal tube had been clamped, cardiac arrest was present in 24 pigs and remained untreated for another 8 minutes. After 4 minutes of basic l...

Dudley and Marrian (1) were the first to show that liver glycogen disappears in fasting animals when insulin is injected. Cannon, McIver, and Bliss (2) found that insulin hypoglycemia leads to an increased discharge of epinephrine. Furthermore, there was general agreement that epinephrine mobilizes liver glycogen. By linking these three facts together, a strong case was made out for the asSumpt...

The purpose of this study was to determine whether physiologic doses of epinephrine reverse the electrophysiologic effects of quinidine in patients with an accessory atrioventricular (AV) connection. Eighteen patients with an accessory AV connection who had inducible sustained orthodromic tachycardia underwent an electrophysiologic study in the baseline state and after at least 2 days of treatm...

Allergy skin testing is considered a safe method for testing for IgE-mediated allergic responses although anaphylactic events can occur. Reported rates of anaphylaxis per patient are not consistent and range from 0.008 to 4%. The aim of this study was to determine the rate of epinephrine use associated with allergy skin-prick testing (SPT) and intradermal testing (IDT) in a suburban practice ov...

BACKGROUND This study was designed to compare differences in intraoperative blood loss, mean arterial blood pressure (MABP), and duration of surgery when 0.25% bupivacaine with 1:200000 epinephrine is injected, preoperatively, versus normal saline (NS), during functional endoscopic sinus surgery (FESS). METHODS A prospective, double-blind randomized placebo-controlled study was performed. Par...

A recent study demonstrated that an epidural test dose containing 15 micrograms epinephrine was an imperfect marker for intravascular injection during isoflurane anesthesia based on the conventional heart rate (HR) criterion (positive if > or = 20 bpm increase). We have determined the effects of epinephrine doses and isoflurane concentrations on these efficacies in healthy adult patients during...

This investigation summarizes the effect of epinephrine administration on milk production and plasma hormones. The epinephrine and nor-epinephrine hormone are released during stress and may have adverse effect on milk yield of lactating animals. Lactating cows were administered epinephrine intravenously (@0.5 ug/kg body wt./ day) for a period of five days. Blood samples were collected before an...

The purpose of our study was to determine whether an infusion of epinephrine reverses the electrophysiologic effects of verapamil and whether reversal of verapamil's effects on the induction of paroxysmal supraventricular tachycardia (PSVT) by epinephrine during electropharmacologic testing is predictive of stress-related recurrences of PSVT during long-term treatment with verapamil. The infusi...

OBJECTIVES To review the literature addressing whether the use of vasopressors improves outcomes in patients who suffer cardiac arrest. METHODS Databases were searched using the terms: "(adrenaline or noradrenaline or vasopressor) and (heart arrest or cardiac arrest) and therapy". Inclusion criteria were human studies, controlled trials, meta-analysis or case series. Exclusion criteria were a...