Dudley and Marrian (1) were the first to show that liver glycogen disappears in fasting animals when insulin is injected. Cannon, McIver, and Bliss (2) found that insulin hypoglycemia leads to an increased discharge of epinephrine. Furthermore, there was general agreement that epinephrine mobilizes liver glycogen. By linking these three facts together, a strong case was made out for the asSumpt...

Epinephrine and β-adrenergic agonists (β1 and β2 for isoproterenol, β1 for dobutamine, β2 for salbutamol) stimulated K+ (or86Rb) influx mediated by the Na+-K+-2Cl-cotransporter and the Na+-K+pump in isolated colonic crypt cells. Preincubation with bumetanide abolished the epinephrine effect on the Na+-K+pump, suggesting that the primary effect is on the cotransporter. Maximal effect was obtaine...

Circulating epinephrine may facilitate neural release of norepinephrine both during and after periods of sympathoadrenal activation by stimulation of prejunctional beta-adrenergic receptors. The present study was undertaken to examine possible effects and aftereffects of epinephrine on the hemodynamic reactivity to mental stress. To this end, two strictly standardized mental stress tests were p...

THE PRESENT STUDIES WERE UNDERTAKEN TO ASSESS THE ADRENERGIC MECHANISMS BY WHICH EPINEPHRINE STIMULATES GLUCOSE PRODUCTION AND SUPPRESSES GLUCOSE CLEARANCE IN MAN: epinephrine (50 ng/kg per min) was infused for 180 min alone and during either alpha (phentolamine) or beta (propranolol)-adrenergic blockade in normal subjects under conditions in which plasma insulin, glucagon, and glucose were mai...

cases at intervals of 2,3 davs showed the following results : Results -50% and above (+), and -49% or less (-) a) 22 cases of uniform results (59.5%) (-) in both tests ........................... 5 (+) in both tests ........................... 17 b) 15 cases of discrepant results (40.5%) (+) in ACTH test and (-) in epinephrine test......... 2 (-) in ACTH test and (+) in epinephrine test...........

BACKGROUND During the administration of advanced cardiac life support for resuscitation from cardiac arrest, a combination of vasopressin and epinephrine may be more effective than epinephrine or vasopressin alone, but evidence is insufficient to make clinical recommendations. METHODS In a multicenter study, we randomly assigned adults with out-of-hospital cardiac arrest to receive successive...

OBJECTIVE During implant surgery, a large amount of local anesthetics containing epinephrine are often required, and the resulting cardiovascular effects of administered epinephrine are not negligible. On the other hand, sedation has wide applications in implant surgery. Nitrous oxide, propofol, or midazolam are commonly used as sedative drugs, and each has also its own cardiovascular effects. ...

Aim: To assess the role of Intraprostatic injection epinephrine intra-operatively in patients undergoing TURP decreasing blood loss and need for subsequent transfusions. Design: A double-blind, randomized controlled trial. Place duration study: The Kidney Centre Postgraduate Training Institute, Karachi, from March till August 2020. Methodology: total 40 were chosen at random divided into two gr...

Although an individual's genetic makeup is a major determinant of muscle mass, other influences, such as hormones, cytokines, nutrition, and exercise can also modulate muscle size. IL-6 is an important inflammatory cytokine. Mice that overexpress IL-6 fail to thrive and/or have reduced skeletal muscle mass. The purpose of the present study was to determine whether the stress hormone epinephrine...

The effects of endotoxin on the epinephrine reactivity of blood vessels in the rat mesoappendix have been studied. Following intravenous injection of a relatively small, sublethal dose of endotoxin, the terminal arterioles and venules exhibited greatly augmented and prolonged vasoconstrictor responses to epinephrine and norepinephrine. Hyperreactivity became evident within 30 minutes after inje...