1. Intact WI-38 human diploid lung fibroblasts were shown to respond to epinephrine (3 X lop7 M) and prostaglandin El (PGE1) (0.57 X lop7 M) with increased cyclic adenosine 3’: 5’-monophosphate (cyclic AMP) levels. Corticotropin (1.25 units per ml), insulin (0.02 to 200 milliunits per ml), and glucagon (5 X lo-’ M) were ineffective. Although the response to PGE, was not clearly maximal at conce...

PURPOSE Epinephrine is an effective drug for glaucoma treatment. However, the mechanisms responsible for the ocular hypotensive action of this compound are not completely understood. Adenosine is an autacoid released by all cells. This study evaluated the role of adenosine receptor activation in epinephrine-induced changes in ocular function. METHODS Rabbits were pretreated topically with the...

BACKGROUND Published surveys depicting the increase in the incidence of food allergy, especially peanut or tree nut allergy, in children have not reported any differences in race, ethnicity, or socioeconomic status. OBJECTIVE To analyze the demographics of schoolchildren with diverse racial, ethnic, and socioeconomic characteristics dispensed injectable epinephrine. METHODS School nurses in...

Horowitz, Jeffrey F., Renata J. Braudy, Wade H. Martin III, and Samuel Klein. Endurance exercise training does not alter lipolytic or adipose tissue blood flow sensitivity to epinephrine. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E325–E331, 1999.—We evaluated the relationship between lipolysis and adipose tissue blood flow (ATBF) in response to epinephrine and the effect of endurance exercis...

BACKGROUND Although numerous studies have explored the benefit of using nebulized epinephrine or corticosteroids alone to treat infants with bronchiolitis, the effectiveness of combining these medications is not well established. METHODS We conducted a multicenter, double-blind, placebo-controlled trial in which 800 infants (6 weeks to 12 months of age) with bronchiolitis who were seen in the...

STUDY OBJECTIVES We have shown in previous studies that epinephrine administered intranasally is a feasible route of administration during cardiopulmonary resuscitation (CPR). To promote the absorption of epinephrine we administered phentolamine prior to epinephrine and used a bile salt as a vehicle to dissolve the epinephrine. The purpose of this study was to compare the effect of two differen...

Objective. A combination of vasopressin and epinephrine may be more effective than epinephrine alone in cardiopulmonary resuscitation (CPR), but evidence is lacking to make clinical recommendations. This meta-analysis compares the efficacy of vasopressin and epinephrine used together versus epinephrine alone in cardiac arrest (CA). Methods. We searched MEDLINE and EMBASE for randomized trials c...

BACKGROUND Initial food-allergic reactions are often poorly recognized and under-treated. METHODS Parents of food-allergic children were invited to complete an online questionnaire, designed with Kids with Food Allergies Foundation, about their children's first food-allergic reactions resulting in urgent medical evaluation. RESULTS Among 1361 reactions, 76% (95% CI 74-79%) were highly likel...

evaluation of the effectiveness of cooling by cryosurgery in cat's inflamed pulp anesthesia dr. s. moradi* - dr. a. talati* - dr. h. hassanabadi** - dr. p. ghaziani*** - dr. m. ehsani**** *-assistant professor of endodontics dept. – faculty of dentistry – mashhad university of medical sciences. **- assistant professor of phisiotherapy dept. – faculty of medicine – mashhad university of med...