Introduction: Countries like Bangladesh have seen an increase in the prevalence of bronchial asthma. The goal study was to compare efficacy nebulized salbutamol and epinephrine treating children with acute Objectives: To assess clinical improvement asthma following nebulization epinephrine. Methodology: This random, double-blind trial conducted paediatric department Mymensingh Medical College H...

Intramuscular (IM) epinephrine via autoinjector has suboptimal compliance/use; alternatives are needed. We compared bioavailability and cardiovascular effects of intranasal (IN) nasal spray versus IM epinephrine. This open-label, randomized, 5-treatment, 5-way crossover study included 25 healthy participants aged 19–45 years. Epinephrine administrations were: 6.6-mg IN (1x6.6-mg), 4.4-mg (2x2.2...

Epinephrine (adrenaline) is the treatment of choice for anaphylaxis. While other medications, including H1-antihistamines, H2-antihistamines, corticosteroids, and inhaled beta-2 agonists are often used to treat anaphylaxis in the emergency setting, none of these medications has been shown to reverse anaphylaxis. Fatal anaphylaxis is related to the delayed use of epinephrine. In community settin...

Trauma associated with infection may directly trigger a neuroendocrine reaction in vivo while the hormone epinephrine is known to mediate immune responses to inflammation after injury. However, the role of epinephrine during the earliest stage of trauma still remains unclear. We therefore explored the role of epinephrine on activated macrophages under LPS stimulation in vitro as well as the mec...

Smolich, Joseph J., and Murray D. Esler. Total body catecholamine kinetics before and after birth in spontaneously hypoxemic fetal lambs. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1313–R1320, 1999.—To study the effect of fetal hypoxemia on perinatal norepinephrine and epinephrine total body kinetics, 13 near-term fetal lambs were instrumented with vascular catheters under...

Neurotransmitters (NTs) are known as endogenous chemical messengers with important roles in the normal functioning of central and peripheral nervous systems. Abnormal levels certain NTs, such dopamine, serotonin epinephrine, have been linked several neurodegenerative diseases (such Alzheimer’s disease, Parkinson’s disease Huntington’s disease). To date, various strategies employed for quantitat...

Phenylalanine hydroxylase in Reuber H4 hepatoma cell cultures can be rapidly inactivated by the addition of epinephrine, norepinephrine, dopamine, or 3,4-dihydroxyphenylalanine, in order of decreasing effectiveness, to the culture medium. The enzyme was 50% inactivated in 1 hour by 25 muM (R)-epinephrine or 45 muM (R)-norepinephrine in the medium. High concentrations of epinephrine caused a 70%...