the effect of epinephrine on phosphatidate phosphohydrolase (pap) activity of isolated human hepatocytes was studied. epineprine inhibited the enzyme activity progressively at concentrations above 0.1 µm, reaching a maximum inhibition of 64.5% at 100 µm concentration. inclusion of alprenolol, a β-receptor blocker, in the incubation mixture abolished the inhibitory effect of epinephrine on pap, ...

 ABSTRACT Background: Acute bronchiolitis is the most common form of lower respiratory tract infection in infancy. There are numerous contradictory reports regarding the efficacy of nebulized bronchodilators in the management of infants with acute bronchiolitis. This study was designed to compare the efficacy of nebulized epinephrine with salbutamol for treatment of the disease. Methods: In a r...

in this study, incorporation of iron ion-doped natrolite nanozeolite, multi-wall carbon nanotubes into chitosan-coated glassy carbon electrode for the simultaneous determination of ascorbic acid, epinephrine, uric acid and tyrosine is studied. the results show that the combination of multi-wall carbon nanotubes and iron ion-doped natrolite zeolite causes a dramatic enhancement in the sensitivit...

Epinephrine has been co-administered intradermally with an anesthetic for intraoperative hemostasis in dermatology nearly a century at concentration of 1:100,000. Many patients report undesirable side effects such as diaphoresis and tachycardia after repeated injections making it difficult them to tolerate procedures. Currently there is ongoing shortage epinephrine that presented opportunity re...

BACKGROUND The intranasal (IN) administration of epinephrine could be an alternative route for anaphylaxis treatment. Although IN epinephrine absorption has been demonstrated in animals, such data in humans are still lacking. OBJECTIVE To study the pharmacokinetics of IN epinephrine absorption in humans. METHODS Each healthy adult (n = 5) was administered IN saline, IN epinephrine at variou...