-According to the "epinephrine hypothesis," circulating epinephrine taken up by sympathetic nerves is coreleased with norepinephrine during sympathetic stimulation and binding of coreleased epinephrine to presynaptic beta-adrenoceptors augments exocytotic release of norepinephrine, contributing to high blood pressure. This study examined whether infusion of a physiologically active amount of ep...

Anaphylaxis is a life-threatening allergic reaction involving multiple organ systems that can result in significant morbidity and mortality if left untreated. Epinephrine the mainstay of treatment. Most episodes anaphylaxis resolve after single dose epinephrine, but biphasic protracted courses are well described. The need for additional doses epinephrine poses challenge wilderness setting, beca...

background: central obesity and hyperinsulinaemia of polycystic ovary syndrome (pcos) are associated with chronic sympathetic over activity. objective: to evaluate the autonomic functions and to indicate the superiority, if any, for those functions in the diagnosis of sympathetic over activity in pcos women. materials and methods: sixty-four pcos patients and 40 women served as the control grou...

BACKGROUND The effectiveness of epinephrine administration for cardiac arrests has been shown in animal models, but the clinical effect is still controversial. METHODS AND RESULTS A prospective, population-based, observational study in Osaka involved consecutive out-of-hospital cardiac arrest (OHCA) patients from January 2007 through December 2009. We evaluated the outcomes among adult non-tr...

INTRODUCTION In septic patients, an unpredictable response to epinephrine may be due to pharmacodynamic factors or to non-linear pharmacokinetics. The purpose of this study was to investigate the pharmacokinetics of epinephrine and its determinants in patients with septic shock. METHODS Thirty-eight consecutive adult patients with septic shock were prospectively recruited immediately before e...

Background Anaphylaxis is a potentially fatal condition; in severe cases of anaphylaxis, the cardiovascular system often heavily involved. Adrenaline (epinephrine) cornerstone initial treatment anaphylaxis. The use epinephrine remains below expectations clinical practice. Whether underuse affects prognosis patients with anaphylaxis still unclear. Materials and methods This retrospective study i...

T HE CURRENT STUDY was suggested by the observation that various substances are capable of potentiating the inotropic response of the papillary muscle to epinephrine. The object of the study has been to obtain information about the nature of the action by which such substances as cysteine, cystine, tyrosine, ascorbic acid, and plasma are capable of producing this potentiation. Four possible sit...

Exercise induces increased levels of plasma interleukin-6 (IL-6) as well as changes in the concentration of lymphocytes and neutrophils. The aim of this study was to investigate a possible role for epinephrine. Seven healthy men participated in an exercise experiment. One month later they received an epinephrine infusion. The exercise consisted of treadmill running at 75% of maximal O(2) consum...

T HE CURRENT STUDY was suggested by the observation that various substances are capable of potentiating the inotropic response of the papillary muscle to epinephrine. The object of the study has been to obtain information about the nature of the action by which such substances as cysteine, cystine, tyrosine, ascorbic acid, and plasma are capable of producing this potentiation. Four possible sit...