De-protected arabino N-glycosyl sulfamides, sulfonamides and sulfamates were found to mutarotate and convert from the furanose to the thermodynamically more stable pyranose form in aqueous solution. The presence of a strongly electron withdrawing group in the alkyl chain stopped mutarotation and furanose/pyranose equilibration, allowing the isolation of the first unprotected furanose N-glycosyl...

Adjuvant treatment of early breast cancer has experienced major changes in the last 25 years. Since the mid 1970s, when cyclophosphamide, methotrexate and fluorouracil (CMF) resulted in statistically significant and clinically meaningful improvements in disease-free and overall survival, the use of adjuvant chemotherapy has become common practice worldwide. Anthracyclines are considered to be a...

Systemic identification of deterministic genes for different phenotypes is a primary application of high-throughput expression profiles. However, gene expression differences cannot be used when the differences between groups are not significant. Therefore, novel methods incorporating features other than expression differences are required. We developed a promising method using transcriptional r...

Over a 30 month period from 1987 to 1990, selective hepatic cannulation under fluoroscopic control was performed in 57 consecutive patients with primary and secondary malignancies of the liver. Fifty-three patients were subsequently treated using intra-arterial Lipiodol emulsified with epirubicin. The tumours treated were hepatocellular carcinoma (n = 35), metastatic adenocarcinoma (n = 14), in...

The EI-MS fragmentation mechanism of the bacterial sesquiterpene epi-isozizaene was investigated through enzymatic conversion of all 15 synthetic ((13) C1 )FPP isotopomers with the epi-isozizaene synthase from Streptomyces albus and GC-MS and GC-QTOF analysis including MS-MS. A systematic method, which we wish to call position-specific mass shift analysis, for the identification of the full set...

Nanomultiple CaFe2O4/ZnFe2O4pn junctions are prepared by a pulsed laser deposition method to explore their photoelectrochemical properties as the photoelectrodes. It is demonstrated that the multiple-pn-junction structure is favorable to enhancing the photocurrent density and the onset potential of the photoelectrode. Furthermore, the 20-junction photoelectrode-based PEC cell yields a high open...

The high frequency of recurrence and poor survival rate of bladder cancer demand exploration of novel strategies. Biotherapy strategies include immunotherapy, gene therapy, inducing cell apoptosis, and so on. Precious studies indicated that BCG could effectively prevent tumor recurrence, and significantly reduce tumor progression. Our studies showed that BCG combined with epirubicin

RESULTS According to the European Association of Urology (EAU) Guidelines for non-muscle invasive bladder cancer (NMIBC) bladder preservation strategies available include: intravesical immunotherapy, intravesical chemotherapy, device-assisted therapy and combination therapy. In Serbia, there are three medicines listed for chemotherapy (doxorubicin, epirubicin and mitomycin) and one for intraves...