We read with great interest the article by Larghi et al. [1], a multicenter cohort study about prevalence and risk factors of extrapancreatic malignancies (EPMs) in patients with intraductal papillary mucinous neoplasm (IPMN) of the pancreas. They concluded that their prevalence was high, especially for colorectal carcinoma, renal cell and thyroid cancers. IPMN harbored some genetic mutations i...

PhD. Postgraduate student, Department of Pediatrics, Division of Pediatric Gastroenterology, Universidade Federal de São Paulo — Escola Paulista de Medicina (Unifesp-EPM), São Paulo, Brazil. PhD. Attending physician, Department of Pediatrics, Division of Pediatric Gastroenterology, Universidade Federal de São Paulo — Escola Paulista de Medicina (Unifesp-EPM), São Paulo, Brazil. PhD. Professor, ...

Rats exposed to an elevated plus maze (EPM) with four open arms display antinociception while on the maze and hyperalgesia immediately upon removal. Little is known about the neural mechanisms underlying EPM-induced antinociception and the subsequent hyperalgesia except that the antinociception is not mediated by endogenous opioids. The objective of the present study was to test the hypothesis ...

MD. Physician in the Breast Group of the Department of Gynecology, Universidade Federal de São Paulo — Escola Paulista de Medicina (Unifesp-EPM), São Paulo, Brazil. MD. Physician in the Department of Gynecology, Universidade Federal de São Paulo — Escola Paulista de Medicina (Unifesp-EPM), São Paulo, Brazil. MD, PhD. Chief professor of Gynecology, Mastology Sector, Department of Gynecology, Uni...

There is a growing trend toward electronic performance monitoring (EPM) to track the performance of workers engaged in computer-based tasks. Despite the possible productivity advantages of this approach to work management, the use of EPM may produce stress through work overload, negative computer feedback, loss of incentive pay and threat of job loss. These stress effects are most likely to occ...

Equine protozoal myeloencephalitis (EPM) can be caused by either of 2 related protozoan parasites, Sarcocystis neurona and Neospora hughesi, although S. neurona is the most frequent etiologic pathogen. Horses are commonly infected, but clinical disease occurs infrequently; the factors influencing disease occurrence are not well understood. Risk factors for the development of EPM include the pre...

OBJECTIVE To quantify modification of functional capacity in a three year period in a group of patients with rheumatoid arthritis (RA) using HAQ and EPM-ROM inventories. METHODS Forty patients with RA on methotrexate (MTX) as disease-modifying anti rheumatic drug (DMARD) were followed for up to three years. The functional status was assessed at the beginning and end of the period by HAQ and E...

It has been demonstrated that exposure to a variety of stressful experiences enhances fearful reactions when behavior is tested in current animal models of anxiety. Until now, no study has examined the neurochemical changes during the test and retest sessions of rats submitted to the elevated plus maze (EPM). The present study uses a new approach (HPLC) by looking at the changes in dopamine and...

BACKGROUND Biological pacemakers (BPM) implanted in canine left bundle branch function competitively with electronic pacemakers (EPM). We hypothesized that BPM engineered with the use of mE324A mutant murine HCN2 (mHCN2) genes would improve function over mHCN2 and that BPM/EPM tandems confer advantage over either approach alone. METHODS AND RESULTS In cultured neonatal rat myocytes, activatio...

Recent development of open-loop electric potential microscopy (OL-EPM) has enabled to measure local potential distribution at a solid/liquid interface. However, the operating environment of OL-EPM has been limited to a weak electrolyte solution (<1 mM). This has significantly limited its application range in biology and chemistry. To overcome this limitation, we have developed dual frequency (D...