نتایج جستجو برای: equine antivenom

تعداد نتایج: 14573  

Journal: :Archives of internal medicine 1999
L V Boyer S A Seifert R F Clark J T McNally S R Williams S P Nordt F G Walter R C Dart

BACKGROUND Coagulation abnormalities following crotaline (pit viper) snakebite have traditionally been considered short-lived, but laboratory studies have rarely been reported beyond the first few days of treatment for envenomation. During the course of an antivenom clinical trial, we observed coagulation defects as late as 2 weeks following envenomation. OBJECTIVES To document and characteri...

2011

In the present study, snakebites caused by a single Bothrops pauloensis simultaneously affecting three male adult horses are described. Whereas the first two affected horses were six years old, the third was 16 years old; they weighed respectively 555, 550 and 500 kg. All horses presented swollen muzzles. The first animal received an initial antivenom dose of 19 vials and adjuvant medication, i...

Journal: :Journal of proteomics 2009
José María Gutiérrez Bruno Lomonte Guillermo León Alberto Alape-Girón Marietta Flores-Díaz Libia Sanz Yamileth Angulo Juan J Calvete

Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact, particularly in Asia, Africa and Latin America. A global initiative, aimed at increasing antivenom production and accessibility, is being promoted by the World Health Organization and others. This work discusses several aspects of antivenom manufacture and control in which the proteomic analysis ...

2017
Elham Valikhanfard-Zanjani Abbas Zare-Mirakabadi Ehsan Zayerzadeh

BACKGROUND Nowadays use of specific antivenin for latrodectism is considered as the most effective treatment in the world. This study was undertaken to investigate the efficacy of specific antivenom against histopathological complications caused by Latrodectus dahli venom on liver, heart and kidneys tissues within 72h. METHODS Two groups were selected, each one contained 6 male New Zealand ra...

2017
Davinia Pla Yania Rodríguez Juan J. Calvete

Second generation antivenomics is a translational venomics approach designed to complement in vivo preclinical neutralization assays. It provides qualitative and quantitative information on the set of homologous and heterologous venom proteins presenting antivenom-recognized epitopes and those exhibiting impaired immunoreactivity. In a situation of worrying antivenom shortage in many tropical a...

2014
Toru Hifumi Atsushi Sakai Akihiko Yamamoto Masahiro Murakawa Manabu Ato Keigo Shibayama Akihiko Ginnaga Hiroshi Kato Yuichi Koido Junichi Inoue Yuko Abe Kenya Kawakita Masanobu Hagiike Yasuhiro Kuroda

BACKGROUND Yamakagashi (Rhabdophis tigrinus) is a species of pit viper present throughout Russia and Eastern Asia. Although R. tigrinus venom is known to induce life-threatening hemorrhagic symptoms, the clinical characteristics and effective treatment of R. tigrinus bites remain unknown. The present study aimed to clarify these issues. METHODS Records in the Japan Snake Institute between 200...

2017
Nicole M. Ryan Nicholas A. Buckley Andis Graudins

Latrodectism or envenomation by widow-spiders is common and clinically significant worldwide. Alpha-latrotoxin is the mammalian-specific toxin in the venom that results in toxic effects observed in humans. Symptoms may be incapacitating and include severe pain that can persist for days. The management of mild to moderate latrodectism is primarily supportive while severe cases have variously bee...

2017
Bin-Sin Liu Wen-Guey Wu Min-Han Lin Chi-Han Li Bo-Rong Jiang Suh-Chin Wu Chih-Hsiang Leng Wang-Chou Sung

Assessing the neutralization capability of nonlethal but medically relevant toxins in venom has been a challenging task. Nowadays, neutralization efficacy is evaluated based simply on the survival rates of animals injected with antivenom together with a predefined dose of venom, which can determine potency against neurotoxicity but not validate the capability to neutralize cytotoxin-induced com...

2017
Ali Duman Bekir Dagli Ayhan Akoz Mucahit Avcil Serhat Orun Kenan Ahmet Turkdoğan Adnan Menderes

The management of scorpion stings, especially those including antivenom treatment, remains a subject of controversy. The purpose of this study was to offer the epidemiologic and clinical characteristics of patients with scorpion sting and to determine the efficacy of antivenom treatment in the management of these patients. A total of 106 adult patients admitted for scorpion sting to our ED betw...

1995
S. Balu C. Alagesaboopathi

Antivenom activities of the alcoholic extracts of three species of Andrographis wall, were measured at a concentration of 10,25,50,75 and 100 μg/ml by in vitro assay of HRBC membrane lysis. All the extracts were found to be effective in the inhibition of in vitro HRBC lysis. The maximum antivenom activity was found in the alcoholicextract of Andrographis paniculata Nees.

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