Erk veya bir diğer ifadeyle güç kavramı, çok katmanlı anlamlar yığınını içinde barındırmasının yanı sıra özünde birtakım sorunsalları da beraberinde getirir. Bu nedenledir ki kavrama ilişkin ortak tanımdan söz etmek oldukça güçtür. Erk, insanoğlunun dünyaya ilk ayak bastığı andan itibaren devinimine başlamıştır. Pozitif bilimlerin beşerî bilimlerde de sürekli olarak sorunsallaştırılmakta ve bu,...

Abstract Background Lung adenocarcinoma (LUAD) metastasis significantly reduces patient survival; hence inhibiting the metastatic ability of lung cancer cells will greatly prolong survival. Alkaline phosphatase (ALPL), a homodimeric cell surface phosphohydrolase, is reported to play controversial role in prostate and ovarian migration; however, function ALPL LUAD related mechanisms remain uncle...

Background and aims: Vitiligo, a pigmentation-associated disease, affects 1–2% of the global population andis difficult to treat. The pathogenetic mechanism vitiligo remains unclear. Vernonia anthelmintica (L.) Willd. extract for treatment was initially recorded 300 years ago. Itschalcone compounds are believed play essential roles in this treatment. In previous study, chalcones were shown enha...

Abstract INTRODUCTION Anti-PD-1 immunotherapy induces clinical responses in a subset of glioblastoma (GBM) patients. We previously reported that ERK1/2 phosphorylation (p-ERK) pre-treatment tumor samples is predictive overall survival (OS) following adjuvant anti-PD-1 therapy two independent cohorts recurrent GBM METHODS Following the Remark criteria for biomarker validation, we investigated p-...

We introduce a technique that makes every explicit Runge--Kutta (ERK) time stepping method invariant domain preserving and mass conservative when applied to high-order discretizations of the Cauchy problem associated with systems nonlinear conservation equations. The key idea is at each stage ERK scheme one computes low-order update, both defined from same intermediate stage, then applies nonli...

Extracellular signal-regulated kinases (ERK) and mitogen-activated protein (MAP) kinases participate in cell signaling, regulating cell growth. In differentiated cells, the role ERK plays is less well known. This study quantified the degree of basal and stimulated ERK phosphorylation and contraction in freshly isolated arteries. The level of basal ERK phosphorylation was identical in preloaded ...

Examined was extracellular-signal regulated kinase (ERK) activation in normal human kidney (n = 2) and a cohort of glomerulopathies by immunohistochemistry staining for the dual-phosphorylated form of ERK (p-ERK). Cell proliferation was determined by expression of the proliferating cell nuclear antigen (PCNA). In normal human kidney, p-ERK was largely restricted to the cytoplasm of cells of the...

Many different viruses activate the extracellular signal-regulated kinase (ERK)/mitogen-activated protein (MAP) kinase signaling pathway during infection and require ERK activation for the efficient execution of their replication programs. Despite these findings, no virus-encoded proteins have been identified that directly modulate ERK activities. In an effort to determine the function of a con...

Extracellular signal-regulated kinase (ERK) is an important intermediate in signal transduction pathways that are initiated by many types of cell surface receptors. It is thought to play a pivotal role in integrating and transmitting transmembrane signals required for growth and differentiation. Constitutive activation of ERK in fibroblasts elicits oncogenic transformation, and recently, consti...