Accumulating evidence implicates innate immune activation in the pathobiology of myelodysplastic syndromes. A key myeloid-related inflammatory protein, S100A9, serves as a Toll-like receptor ligand regulating tumor necrosis factor-α and interleukin-1β production. The role of myelodysplastic syndrome-related inflammatory proteins in endogenous erythropoietin regulation and response to erythroid-...

Prof. Dr. Kuddusi Cengiz, Ondokuz Mayis University School of Medicine, Department of Nephrology, TR-55139 Samsun (Turkey) Dear Sir, The correction of anemia in hemodialysis patients with human recombinant erythropoietin increases appetite, anabolic effects, and improves physical, psychological activities and endocrine functions. As the sense of well-being improves, the patients increase food in...

OBJECTIVE To assess the cost benefits of low dose subcutaneous recombinant human erythropoietin in correcting the anaemia of end stage renal disease. DESIGN Three year retrospective study. SETTING Subregional nephrology service serving a mixed urban and rural population of 800,000. SUBJECTS 60 patients with symptoms of anaemic end stage renal disease treated with erythropoietin (43 receiv...

Dysregulated erythropoietin (EPO) plasma levels may play a role in the patho physiology of chronic liver disease (CLD) [1] because chronic anaemia is frequently observed in patients with liver cirrhosis. Some reports have used regular short acting Erythropoietin as well as low dose long acting Erythropoietin and regular short acting Granulocyte colony stimulating factor (Filgrastim) in liver ci...

The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NFkappaB-immunoreactive neurons were o...

Purpose. To study suppressor and/or cytotoxic activity of the nuclear erythroid cells (NEC) against tumor various origins. Material and Methods. C57Bl/6 mice P815, L1210, B16 L929 were used. “Phenylhydrazine” NECs obtained from with induced hemolytic anemia. “Erythropoietin” isolated “phenylhydrazine spleen” further cultured in presence erythropoietin. Another source NEC was neonatal mouse sple...

A family is described in which four members spanning three consecutive generations have erythrocytosis associated with a normal hemoglobin oxygen affinity. When bone marrow from one affected family member was cultured in vitro, erythroid colonies formed only when erythropoietin was added to the culture. Serum erythropoietin, measured by radioimmunoassay. was significantly elevated above normal ...

We performed in vitro culture studies examining the interaction of erythropoietin with red cell progenitors in polycythemia vera. Bone marrow was obtained from five patients with typical disease and from five healthy volunteers, and assayed for erythroid colony formation (CFU-E) by the methylcellulose technique. In cultures without added erythropoietin, a mean eightfold greater cloning efficien...

During the past decade, accumulating evidence from both clinical and experimental studies has indicated that erythropoietin may have antidepressant effects. In addition to the kidney and liver, many organs have been identified as secretory tissues for erythropoietin, including the brain. Its receptor is expressed in cerebral and spinal cord neurons, the hypothalamus, hippocampus, neocortex, dor...

Erythropoietin production in response to hypoxic-hypoxia is markedly reduced in the newborn when compared to the adult rat. This response improves steadily with age and reaches adult values at about 4 wk. When animals of the same age are stimulated with anemic-hypoxia, considerably higher levels of erythropoietin are found. The erythropoietin level is proportional to the degree of anemia and in...