purpose: microgravity causes major changes in various systems of the body in space, such as shift in cerebrospinal fluid, decreased red blood cells count, and electrolyte loss. these complications are very important in space and we should find new approaches to prevent the side effects of microgravity in astronauts. materials and methods: this experimental study was conducted on 21 adult male r...

abstract background: very low birth weight infants ( <1500 g) frequently require blood transfusions because of repeated blood sampling accompanied by anemia of prematurity. methods: in an attempt to identify the effect of human recombinant erythropoietin to decrease the requirement for blood transfusions, erythropoietin was administered to 24 pre term infants less than 1500 g prospectively from...

PURPOSE The use of erythropoietin in head and neck squamous cell carcinoma (HNSCC) has been associated with poor survival. This study examines the protein and mRNA expression of erythropoietin and erythropoietin receptor in HNSCC and their relation to hypoxia, hemoglobin (Hb), and clinical outcome. EXPERIMENTAL DESIGN The immunohistochemical expression of erythropoietin and erythropoietin rec...

Although anemia may cause angiogenesis and neovascularization, especially in ocular situations, neither published nonrandomized clinical trials nor registered have reported the status as inclusion or exclusion criteria their design. Increases circulating levels of erythropoietin vascular endothelial growth factor are proportional to tissue hypoxia, which influenced by hematocrit. Erythropoietin...

Erythropoietin is an essential growth factor that promotes survival, proliferation, and differentiation of mammalian erythroid progenitor cells. Erythropoietin(-/-) and erythropoietin receptor(-/-) mouse embryos die around embryonic day 13.5 due, in part, to failure of erythropoiesis in the fetal liver. In this study, we demonstrated a novel role of erythropoietin and erythropoietin receptor in...

Carbamylated erythropoietin (cEpo), which is neuroprotective but lacks hematopoietic activity, has been attracting rising concerns. However, the cellular and molecular mechanisms involved in the process of neuroprotection of cEpo are not well known. Based on several recent reports, the neuroprotective effects of cEpo are illustrated, and signaling pathways involved in the different effects of e...

Cerebral ischemia causes death of millions people all over the world, annually and also suffering more people from neurological deficits and neuromuscular disorders. In our country, 250 to 300 people experience mild to severe stroke, daily. In this study we reviewed 120 original paper selected from PubMED database. Our keywords were erythropoietin, anti-inflammatory, stroke, neuropathy and cere...

Introduction: One of the functions kidneys is production erythropoietin, a signaling molecule that stimulates red blood cells, in response to reduced oxygen levels blood. In chronic kidney disease, there disturbance erythropoietin. Several previous studies have linked index erythropoietin resistance mortality patients with disease. The study aimed correlate between (ERI) and Mortality regular h...