Despite sharing many common features, adenine-binding and guanine-binding sites in proteins often show a clear preference for the cognate over the non-cognate ligand. We have analyzed electrostatic potential (ESP) patterns at adenine and guanine-binding sites of a large number of non-redundant proteins where each binding site was first annotated as adenine/guanine-specific or non-specific from ...

As the core issue of blockchain, the mining requires solving a proof-of-work puzzle, which is resource expensive to implement in mobile devices due to high computing power needed. Thus, the development of blockchain in mobile applications is restricted. In this paper, we consider the edge computing as the network enabler for mobile blockchain. In particular, we study optimal pricing-based edge ...

This paper considers the calculation of a Euclidean shortest path (ESP) in a three-dimensional (3D) polyhedral space Π . We propose an approximate κ(ε) · O(M |V |) 3D ESP algorithm (excluding preprocessing), with preprocessing time complexity O(M |E| + |S| + |V | log |V |), for solving a special, but ‘fairly general’ case of the 3D ESP problem, where Π does not need to be convex, V and E are th...

Partial charges of atoms in a molecule and electrostatic potential (ESP) density for that molecule are known to bear a strong correlation. In order to generate a set of point-field force field parameters for molecular dynamics, Kollman and coworkers have extracted atomic partial charges for each of all 20 amino acids using restrained partial charge-fitting procedures from theoretical ESP densit...

Most bacterial source tracking (BST) methods are too expensive for most communities to afford. We developed targeted sampling as a prelude to BST to reduce these costs. We combined targeted sampling with three inexpensive BST methods, Enterococcus speciation, detection of the esp gene, and fluorometry, to confirm the sources of fecal contamination to beaches on Georgia's Jekyll and Sea Islands ...

High Performance Computing (HPC) technology is being used to provide scalable and cost-eeective solutions to many Embedded Signal Processing (ESP) applications. Such applications are computationally intensive and require real-time performance. To meet such requirements, algorithmic techniques are needed to eeectively utilize available HPC platforms. In this paper, we address the design issues i...

Status of this Memo: This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the " Internet Official Protocol Standards " (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited.

PREFACE Health Services Research & Development Service's (HSR&D's) Evidence-based Synthesis Program (ESP) was established to provide timely and accurate syntheses of targeted healthcare topics of particular importance to Veterans Affairs (VA) managers and policymakers, as they work to improve the health and healthcare of Veterans. The ESP disseminates these reports throughout VA. HSR&D provides...

Annotated corpora of the size needed for modern computational linguistics research cannot be created by small groups of hand annotators. One solution is to exploit collaborative work on the Web and one way to do this is through games like the ESP game. Applying this methodology however requires developing methods for teaching subjects the rules of the game and evaluating their contribution whil...

We estimated global marketed and non-marketed economic value from two classified satellite images with global coverage at 1 km resolution. GDP (a measure of marketed economic output) is correlated with the amount of light energy (LE) emitted by that nation as measured by nighttime satellite images. LE emitted is more spatially explicit than whole country GDP, may (for some nations or regions) b...