Furosemide-sensitive sodium and potassium cotransport and intracellular sodium content ([Na]i) were measured in erythrocytes (red blood cells, RBCs) from a population of 90 adult black men with and without essential hypertension (EH). The mean values for sodium cotransport activity, expressed as furosemide-sensitive Na efflux (mmol/liter RBC/hr), were not significantly different among the EH pa...

The aim of this study was to investigate the association between myeloperoxidase (MPO) gene polymorphisms and carotid atherosclerosis (AS) in patients with essential hypertension (EH). A total of 214 patients with EH were divided into an AS and a non-atherosclerosis (non-AS) group. MPO gene polymorphisms in EH were detected using PCR. The frequency of increased intima-media thickness and the oc...

BACKGROUND Telmisartan and atenolol are widely used in the management of essential hypertension. This study was conducted to compare the efficacy of these two drugs in management of patients of essential hypertension. METHODS Diagnosed patients of essential hypertension were selected. Therapeutic option (telmisartan/atenolol) was allocated to the patients by lottery method and they were divid...

The expression 'hypertensive urgencies' includes many diseases. The unifying features of these diseases are a high level of arterial pressure and acute distress of one or more organs. The aim of the review was to define the idea of the 'acute hypertension' as a new concept, different from 'chronic hypertension'. Acute hypertension might be related to 'organ damage' because it is the cause, the ...

B IOLOGICAL ASSAYS of angiotensin in the blood of patients with normal blood pressures, patients with benign essential hypertension, and patients with malignant hypertension indicate that there are significantly greater quantities of angiotensin in the subjects with benign essential hypertension than in the normotensive group and that the greatest quantities of angiotensin are present in the pa...

Dermatoglyphics is influenced by heredity and abnormality in it are associated with chromosomal anamolies. Primary hypertension is polygenic and the scientific dermatoglyphic pattern analysis are rare, which could be used as a diagnostic and screening aid.The present was done to study the frequency distribution of scientific ridge pattern in primary hypertensives.The study was carried out in 20...

A polypeptide fraction isolated from the urine of normotensive subjects lowers the blood pressure (BP) in a rabbit bioassay (mean BP decrease 33.8% +/- 0.6%, SEM). Patients with primary hypertension exhibit reduced or no activity (mean BP decrease 8.8% +/- 1.2%). In contrast, patients with secondary forms of hypertension show activity like normotensives (mean BP decrease 33.4% +/- 1.0%). The re...

This study was designed to examine short-term blood pressure variability (BPV) in patients with different severity and forms of chronic medically treated hypertension. Power spectral analysis of BPV was performed from continuous finger blood pressure (Finapres) recordings. Ten patients with renovascular hypertension (RVHT), 34 with severe essential hypertension (SEHT) and 29 with mild essential...

HYPERTENSION even of mild degree shortens life span. Thus Dublin, Lotka and Spiegelman1 in 1940 stated, "mortality rises steadily and markedly with increasing elevations of both the systolic and diastolic pressures'? and, '' ii the group with the highest blood pressures included in this [insurance] experience-and these are not considered seriously high by many clinicians-the mortality from card...

Several lines of evidence suggest that the kidney plays an important role in the genesis of primary hypertension in humans and genetic hypertension in animals. Perhaps the most compelling evidence derives from clinical1–4 and experimental renal transplantation studies,5–36 which have been performed over the last 3 decades. In virtually all of these studies, the genetic background of the donor k...