Estrogen might play an important role in the pathogenesis of diabetes mellitus type 2. Estrogens inhibit diabetes via distinct mechanisms particularly by reducing both hyperglycemia and plasma insulin levels. Estrogen exerts its physiological effects mainly through estrogen receptors including α and β types. Estrogen receptors are found in many tissues that participate in the pathogenesis of ty...

Background and aim: Shortening of the duration of wound healing is an attractive subject for investigators in recent years. In this study, the effects of topical phenytoin, silver sulfadiazine, estrogen and their combination on wound healing were evaluated.Materials and Methods: This experimental study was accomplised on 30 male albino rats, which had an approximate wei...

Background & Objective: Gliomas are the most common type of primary intracranial tumors in adults. The expression of estrogen receptors varies in different grades of glial tumors, and some studies have suggested that this expression might have a prognostic value. It seems that estrogen receptor expression negatively correlates with the histological grade of gliomas. In the pres...

Introduction Natural and synthetic estrogens are pollutants found in aquatic ecosystems at low concentrations reaching ng.L -1 to μg.L . At these concentrations, they able interfere with the fish endocrine system. When waterborne exposure occurs early life stages, when blood low, this may have significant consequences for estrogen-sensitive functions such as skeletal development. Methods To bet...

Introduction: Fennel is rich in phytoestrogens and is used for estrogen deficiency disorders. Estrogens affect anxiety through neurochemical systems such as GABA-A receptors. In this study the effects of fennel on GABA-A and estrogen receptors in anxiety were investigated. Methods: Adult female Wistar rats weighing (180±20 g) were divided into 8 groups. Groups received saline, fennel (200, ...

Both estrogen and hydrogen sulfide (H 2 S) inhibit the proliferation of vascular smooth muscle cells (SMCs) development atherosclerosis. In absence endogenous H S as occurred in CSE-knockout (KO) mouse, however, stimulates SMCs. The underlying mechanisms for this seemingly controversial effect are unclear. present study, we demonstrated that stimulatory on CSE-KO SMCs was suppressed by inhibito...

We previously found that cigarette sidestream smoke particulate matter (CSSP) could activate estrogen receptor ERα to generate estrogen-like tumor-promoting effects. This study sought identify the compounds responsible for CSSP estrogenicity. first identified component using a combination of GC-MS and mass spectral matching. Based on computational estrogenicity prediction, nine potential estrog...