Background To attain whether the effects of low and high doses of estrogen progesterone luteinizing hormone (LH) and follicle stimulating hormone (FSH) in acute and chronic administration were related to oxidant and antioxidant parameters in rat uterine tissue as well as cyclooxygenase-1 (COX-1) activity. MaterialsAndMethods Acute and chronic administration of estrogen (1 and 5 mg/ kg) progeste...

Endocrine therapy is the primary treatment for most common types of breast cancer. agents work by inhibiting tumor-stimulating effects estrogen in hormone-sensitive tumors. A new class targeted drugs synergize with endocrine to improve survival patients metastatic disease. continued years, and long-term common, although toxicities often occur due alteration physiologic estrogen. It important, t...

the aims of this study were (a) to establish the occurrence, duration and intensity of behavioral estrus symptoms, and (b) to determine the relationship between behavioral estrus symptoms with the total estrogen profiles in cycling murrah buffaloes (n=10) subjected to doublesynch protocol (0 pgf2α, 2 gnrh, 9 pgf2α and 11 gnrh). after both gnrh injections, estrus and its behavioral signs were de...

objective: estrogen receptor alpha protein status is determined by routine immunohistochemistry analysis in all malignant breast tumors. this assay has its limitations. rna based techniques are potential complements for immunohistochemistry but it must be noticed that gene silencing may occur at different levels from rna to protein. the aim of this study was the comparison of the results from t...

introduction: impaired wound healing in diabetic patients is a major clinical problem, which is associated with significant morbidity and mortality. estrogen has positive effects on neoangiogenesis, reepithelialization and cell proliferation. in this research, effect of estrogen on wound healing in diabetic male rats was investigated. methods: this study was performed on male wistar rats (body ...

background: systemic lupus eyrythematosus (sle) is an autoimmune disease charac-terized by antibodies to nuclear antigens, particularly anti-dsdna. imbalance between production and destruction of immune cells causes cytopenia. sex hormones have im-munomodulatory effects; estrogen increases the production of autoantibodies in sle prone nzb/nzw mice. objective: to investigate the relationship bet...

Objective(s):Estrogen (E2) has neuroprotective effects on blood-brain-barrier (BBB) after traumatic brain injury (TBI). In order to investigate the roles of estrogen receptors (ERs) in these effects, ER-α antagonist (MPP) and, ER-β antagonist (PHTPP), or non-selective estrogen receptors antagonist (ICI 182780) were administered. Materials and Methods: Ovariectomized rats were divided into 10 gr...

Abstract: Aim: Breast cancer is one of the most common cancers among women, consistently elevated estrogen level in blood associated with persistently breast found many studies. The mechanisms carcinogenesis whereby involved conversion androgen to presence enzyme aromatase. Materials and Methods: Aromatase a (CYP19), cytochrome P450, which that synthesizes estrogen. expressed higher concentrati...

Estrogen has pleiotropic effects on the cardiovascular system. The mechanisms by which estrogen confers these pleiotropic effects are undergoing active investigation. Until a decade ago, all estrogen signaling was thought to occur by estrogen binding to nuclear estrogen receptors (estrogen receptor-α and estrogen receptor-β), which bind to DNA and function as ligand-activated transcription fact...